Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney

Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key causative feature, but this has been difficult to test experimentally, and recent studies have challenged this hypothesis. Based on the critical rol...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (47), p.17985-17990
Hauptverfasser:	Crowley, Steven D., Gurley, Susan B., Herrera, Maria J., Ruiz, Phillip, Griffiths, Robert, Kumar, Anil P., Kim, Hyung-Suk, Smithies, Oliver, Le, Thu H., Coffman, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Angiotensin II - metabolism Animals Biological Sciences Blood pressure Blood Pressure - physiology Cardiomegaly Cardiomegaly - metabolism Excretion Gene Expression Regulation Heart Heart - physiology Homeostasis Humans Hypertension Hypertension - metabolism Kidney - metabolism Kidney Transplantation Kidneys Left ventricular hypertrophy Mice Mice, Inbred C57BL Mice, Knockout Myocardium - cytology Myocardium - metabolism Myocardium - pathology Pathology Receptor, Angiotensin, Type 1 - metabolism Receptors Sodium Sodium - urine
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