Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

DNA polymerase ι (pol ι) is a conserved Y family enzyme that is implicated in translesion DNA synthesis (TLS) but whose cellular functions remain uncertain. To test the hypothesis that pol ι performs TLS in cells, we compared UV-induced mutagenesis in primary fibroblasts derived from wild-type mice...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (48), p.18083-18088
Hauptverfasser:	Dumstorf, Chad A, Clark, Alan B, Lin, Qingcong, Kissling, Grace E, Yuan, Tao, Kucherlapati, Raju, McGregor, W Glenn, Kunkel, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Survival - radiation effects Cells, Cultured DNA Damage DNA-Directed DNA Polymerase - deficiency DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Fibroblasts Mice Mice, Knockout Mutagenesis - genetics Sensitivity and Specificity Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Ultraviolet Rays
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