The Nuclear Receptor PXR is a Lithocholic Acid Sensor That Protects against Liver Toxicity

The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. In this study, we demonstrate that PXR is activated by the toxic bile acid lithoch...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-03, Vol.98 (6), p.3369-3374
Hauptverfasser:	Staudinger, Jeff L., Goodwin, Bryan, Jones, Stacey A., Hawkins-Brown, Diane, MacKenzie, Kathleen I., LaTour, Anne, Liu, Yaping, Klaassen, Curtis D., Brown, Kathleen K., Reinhard, John, Willson, Timothy M., Koller, Beverly H., Kliewer, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases Bile acids Biological Sciences Cholestasis, Intrahepatic - metabolism Cholestasis, Intrahepatic - prevention & control Cholesterol 7-alpha-Hydroxylase - genetics cholesterol 7^a-hydroxylase CYP3A gene Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Female Gene expression regulation Gene Expression Regulation, Enzymologic lithocholic acid Lithocholic Acid - metabolism Lithocholic Acid - pharmacology Liver Liver - drug effects Liver - injuries Liver - metabolism Male Medical research Metabolites Mice Mice, Inbred C57BL Mice, Knockout Oatp2 gene Oxidoreductases, N-Demethylating - genetics pregnane X receptors pregnenolone 16^a-carbonitrile Pregnenolone Carbonitrile - pharmacology Receptors Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - physiology Receptors, Steroid - genetics Receptors, Steroid - metabolism Receptors, Steroid - physiology RNA Steroids Toxicity Urine Vehicles
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