Identification of Pulmonary Oct-4⁺ Stem/progenitor Cells and Demonstration of Their Susceptibility to SARS Coronavirus (SARS-CoV) Infection in vitro

In this study, we report a serum-free culture system for primary neonatal pulmonary cells that can support the growth of octamerbinding transcription factor 4⁺ (Oct-4⁺) epithelial colonies with a surrounding mesenchymal stroma. In addition to Oct-4, these cells also express other stem cell markers s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-06, Vol.103 (25), p.9530-9535
Hauptverfasser:	Ling, Thai-Yen, Kuo, Ming-Der, Li, Chung-Leung, Yu, Alice L., Huang, Yen-Hua, Wu, Tsai-Jung, Lin, You-Chin, Chen, Shu-Hwa, Yu, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biomarkers Bromodeoxyuridine Cell culture techniques Cell Differentiation Cell lines Cells, Cultured Cellular immunity Cultured cells Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - virology Gene Expression Regulation Infections Lung - cytology Lung - virology Lungs Mesenchymal stem cells Mice Mice, Inbred ICR Microscopy, Electron, Transmission Octamer Transcription Factor-3 - metabolism SARS virus Severe acute respiratory syndrome-related coronavirus - physiology Stem cells Stem Cells - cytology Stem Cells - metabolism Stem Cells - virology
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