The Role of MicroRNA Genes in Papillary Thyroid Carcinoma

Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs (miRNAs) are transcriptionally up-regulated in PTC tumors compared with unaffected thyroid tissue. A set of five miRNAs, incl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (52), p.19075-19080
Hauptverfasser:	He, Huiling, Krystian Jazdzewski, Li, Wei, Liyanarachchi, Sandya, Rebecca Nagy, Volinia, Stefano, Calin, George A., Liu, Chang-gong, Kaarle Franssila, Suster, Saul, Kloos, Richard T., Croce, Carlo M., de la Chapelle, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Sciences Blotting, Northern Blotting, Western Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Cell lines Computational Biology DNA DNA - metabolism Down-Regulation Gene expression Gene Expression Regulation Gene Expression Regulation, Neoplastic Genes Humans Medical research Messenger RNA MicroRNA MicroRNAs - chemistry Models, Statistical Molecular Sequence Data Mutation Neoplasms - metabolism Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Oncology Polymorphism Polymorphism, Genetic Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - metabolism Sequence Analysis, DNA Software Thyroid cancer Thyroid gland Thyroid Gland - metabolism Thyroid Neoplasms - genetics Thyroid Neoplasms - therapy Tissue samples Tumors Up-Regulation
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