Synergistic Induction of Tissue Factor by Coagulation Factor Xa and TNF: Evidence for Involvement of Negative Regulatory Signaling Cascades

Enzymes of the blood coagulation pathway enhance the inflammatory response leading to endothelial dysfunction, accounting, in part, for the vascular complications occurring in sepsis and cardiovascular disease. The responses of endothelial cell activation include induction of the expression of tissu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-08, Vol.102 (34), p.12077-12082
Hauptverfasser:	Hezi-Yamit, Ayala, Wong, Paul W, Bien-Ly, Nga, Komuves, Laszlo G, Prasad, K S Srinivasa, Phillips, David R, Sinha, Uma
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Biological Sciences Blood Coagulation - physiology CD40 Ligand - metabolism Coagulation Cytokines DNA Primers E-Selectin - metabolism Endothelial cells Endothelial Cells - metabolism Endothelial Cells - physiology Enzymes Factor Xa - metabolism Fluorescent Antibody Technique Gene Expression Regulation Human umbilical vein endothelial cells Humans Immunoblotting Interleukin-1 - metabolism Lead Phosphatases Phosphorylation Receptors Reverse Transcriptase Polymerase Chain Reaction Signal transduction Signal Transduction - physiology Thromboplastin - metabolism Tissues Tumor Necrosis Factor-alpha - metabolism
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