The Candidate Tumor Suppressor ING4 Represses Activation of the Hypoxia Inducible Factor (HIF)

The hypoxia inducible factor (HIF) plays an important role in the progression of a number of pathophysiological processes including tumorigenesis. In addition to several well characterized oxygen-dependent modes of regulation, the function of the HIF transcription factor can also be influenced throu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-05, Vol.102 (21), p.7481-7486
Hauptverfasser:	Ozer, Abdullah, Wu, Leeju C., Bruick, Richard K., McKnight, Steven L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic conditions Biological Sciences Blotting, Western Cell Cycle Proteins Cell Fractionation Cell lines Chromatin Immunoprecipitation Cloning, Molecular DNA-Binding Proteins - metabolism Escherichia coli Family members Gene Expression Regulation Genes Genetic Vectors Glutathione Transferase HeLa Cells Homeodomain Proteins Humans Hypoxia Hypoxia - metabolism Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Immunoprecipitation Models, Biological NF-kappa B - metabolism Nuclear Proteins - metabolism Oxygen - metabolism Procollagen-Proline Dioxygenase - metabolism Proteins RNA Interference Small interfering RNA Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Tumors Two-Hybrid System Techniques
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