Aggregation of Proteins with Expanded Glutamine and Alanine Repeats of the Glutamine-Rich and Asparagine-Rich Domains of Sup35 and of the Amyloid β-Peptide of Amyloid Plaques

The exon-1 peptide of huntingtin has 51 Gln repeats and produces the symptoms of Huntington's disease in transgenic mice. Aggregation of the yeast Sup35 protein into prions has been attributed to its glutamine-rich and asparagine-rich domain. Here, we show that poly-L-asparagine forms polar zip...

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