Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of Ca V 1.1 channels in skeletal muscle

In skeletal muscle cells, voltage-dependent potentiation of Ca 2+ channel activity requires phosphorylation by cAMP-dependent protein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid sites of phosphorylation are located in the C-terminal domain. Surprisingly, the...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2005-04, Vol.102 (14), p.5274-5279
Hauptverfasser: Hulme, Joanne T., Konoki, Keiichi, Lin, Teddy W.-C., Gritsenko, Marina A., Camp, David G., Bigelow, Diana J., Catterall, William A.
Format: Artikel
Sprache:eng
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