c-Myc Regulates Cell Size and Ploidy but Is Not Essential for Postnatal Proliferation in Liver
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation o...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2005-05, Vol.102 (20), p.7286-7291 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Baena, Esther Gandarillas, Alberto Vallespinós, Mireia Zanet, Jennifer Bachs, Oriol Redondo, Clara Fabregat, Isabel Carlos Martinez-A. de Alborán, Ignacio Moreno Alt, Frederick W. |
| description | The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth. |
| doi_str_mv | 10.1073/pnas.0409260102 |
| format | Article |
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In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0409260102</identifier><identifier>PMID: 15857952</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Alleles ; Animals ; Apoptosis ; B lymphocytes ; Biological Sciences ; Bromodeoxyuridine ; Cell cycle ; Cell lines ; Cell Proliferation ; Cell Size ; Cells ; DNA Primers ; Fluoresceins ; Hepatocytes ; Hepatocytes - metabolism ; Immunohistochemistry ; Liver ; Liver - growth & development ; Liver - metabolism ; Mice ; Mice, Knockout ; Ploidies ; Poly I-C ; Polymerase Chain Reaction ; Polyploidy ; Proteins ; Proto-Oncogene Proteins c-myc - deficiency ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; Size</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (20), p.7286-7291</ispartof><rights>Copyright 1993/2005 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences May 17, 2005</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-5edb29399b00f12baae1e3f77c42b1f0c63d6c0fa2fca79b255e89c6f8deda013</citedby><cites>FETCH-LOGICAL-c527t-5edb29399b00f12baae1e3f77c42b1f0c63d6c0fa2fca79b255e89c6f8deda013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/20.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3375523$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3375523$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15857952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baena, Esther</creatorcontrib><creatorcontrib>Gandarillas, Alberto</creatorcontrib><creatorcontrib>Vallespinós, Mireia</creatorcontrib><creatorcontrib>Zanet, Jennifer</creatorcontrib><creatorcontrib>Bachs, Oriol</creatorcontrib><creatorcontrib>Redondo, Clara</creatorcontrib><creatorcontrib>Fabregat, Isabel</creatorcontrib><creatorcontrib>Carlos Martinez-A.</creatorcontrib><creatorcontrib>de Alborán, Ignacio Moreno</creatorcontrib><creatorcontrib>Alt, Frederick W.</creatorcontrib><title>c-Myc Regulates Cell Size and Ploidy but Is Not Essential for Postnatal Proliferation in Liver</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. 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These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.</description><subject>Alleles</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>B lymphocytes</subject><subject>Biological Sciences</subject><subject>Bromodeoxyuridine</subject><subject>Cell cycle</subject><subject>Cell lines</subject><subject>Cell Proliferation</subject><subject>Cell Size</subject><subject>Cells</subject><subject>DNA Primers</subject><subject>Fluoresceins</subject><subject>Hepatocytes</subject><subject>Hepatocytes - metabolism</subject><subject>Immunohistochemistry</subject><subject>Liver</subject><subject>Liver - growth & development</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Ploidies</subject><subject>Poly I-C</subject><subject>Polymerase Chain Reaction</subject><subject>Polyploidy</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-myc - deficiency</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>Size</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1vEzEQxS0EomnhzAWBxQFx2XZsr9frCxKKClQKEPFxxfJ67eJosw62t2r463GUqAEOnEbW_ObNGz-EnhA4JyDYxWbU6RxqkLQBAvQemhGQpGpqCffRDICKqq1pfYJOU1oBgOQtPEQnhLdcSE5n6LupPmwN_myvp0Fnm_DcDgP-4n9ZrMceL4fg-y3upoyvEv4YMr5MyY7Z6wG7EPEypDzqXF7LGAbvbNTZhxH7ES_8jY2P0AOnh2QfH-oZ-vb28uv8fbX49O5q_mZRGU5FrrjtOyqZlB2AI7TT2hLLnBCmph1xYBrWNwacps5oITvKuW2laVzb214DYWfo9V53M3Vr25tiMepBbaJf67hVQXv1d2f0P9R1uFGEUEkAisDLg0AMPyebslr7ZMpf6NGGKSkiWkFrJgr44h9wFaY4luMULUaAcd4U6GIPmRhSitbdOSGgdsGpXXDqGFyZePbnAUf-kFQBXh2A3eRRjpa1StC2UW4ahmxvc0Gf_x8txNM9sUo5xDuEMcHLKvYbdz224A</recordid><startdate>20050517</startdate><enddate>20050517</enddate><creator>Baena, Esther</creator><creator>Gandarillas, Alberto</creator><creator>Vallespinós, Mireia</creator><creator>Zanet, Jennifer</creator><creator>Bachs, Oriol</creator><creator>Redondo, Clara</creator><creator>Fabregat, Isabel</creator><creator>Carlos Martinez-A.</creator><creator>de Alborán, Ignacio Moreno</creator><creator>Alt, Frederick W.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20050517</creationdate><title>c-Myc Regulates Cell Size and Ploidy but Is Not Essential for Postnatal Proliferation in Liver</title><author>Baena, Esther ; 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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; JSTOR |
| subjects | Alleles Animals Apoptosis B lymphocytes Biological Sciences Bromodeoxyuridine Cell cycle Cell lines Cell Proliferation Cell Size Cells DNA Primers Fluoresceins Hepatocytes Hepatocytes - metabolism Immunohistochemistry Liver Liver - growth & development Liver - metabolism Mice Mice, Knockout Ploidies Poly I-C Polymerase Chain Reaction Polyploidy Proteins Proto-Oncogene Proteins c-myc - deficiency Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Size |
| title | c-Myc Regulates Cell Size and Ploidy but Is Not Essential for Postnatal Proliferation in Liver |
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