Ku70 Acetylation Mediates Neuroblastoma Cell Death Induced by Histone Deacetylase Inhibitors

Histone deacetylase inhibitors (HDACIs) are therapeutic drugs that inhibit deacetylase activity, thereby increasing acetylation of many proteins, including histones. HDACIs have antineoplastic effects in preclinical and clinical trials and are being considered for cancers with unmet therapeutic need...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-03, Vol.102 (13), p.4842-4847
Hauptverfasser:	Subramanian, Chitra, Opipari, Anthony W., Bian, Xin, Castle, Valerie P., Roland P. S. Kwok, Goodman, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Antibodies Antigens, Nuclear - metabolism Apoptosis Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein Biological Sciences Butyrates - pharmacology Cell death Cell lines Cell nucleus Cells Cytochromes Cytochromes c - metabolism DNA-Binding Proteins - metabolism Drug therapy Enzymes Flow Cytometry Green Fluorescent Proteins Histone Deacetylase Inhibitors Hydroxamic Acids - pharmacology Immunoblotting Immunoprecipitation Killing Ku Autoantigen Mice Mitochondria - metabolism Neuroblastoma - metabolism Protein Transport Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Transfection Tumor Cells, Cultured Tumors Viability
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