Double-Knockout Mice for α- and β-Synucleins: Effect on Synaptic Functions

An abundant presynaptic protein, α-synuclein, is centrally involved in the pathogenesis of Parkinson's disease. However, conflicting data exist about the normal function of α-synuclein, possibly because α-synuclein is redundant with the very similar β-synuclein. To investigate the functions of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-10, Vol.101 (41), p.14966-14971
Hauptverfasser:	Chandra, Sreeganga, Fornai, Francesco, Kwon, Hyung-Bae, Yazdani, Umar, Atasoy, Deniz, Liu, Xinran, Hammer, Robert E., Battaglia, Giuseppe, German, Dwight C., Castillo, Pablo E., Südhof, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Animals Base Sequence beta-Synuclein Biological Sciences Biological Transport Brain Corpus Striatum - physiology DNA Primers Dopamine - metabolism Electrophysiology Exons Hippocampus - physiology Mice Mice, Knockout Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neurons Neurons - cytology Neurons - physiology Neurons - ultrastructure Neuroscience Neurotransmitters Parkinson disease Proteins Recycling Rodents Synapses Synapses - physiology Synaptic Vesicles - physiology Synaptic Vesicles - ultrastructure Synucleins
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