Cancer Regression in Patients with Metastatic Melanoma after the Transfer of Autologous Antitumor Lymphocytes

Our recent clinical trials demonstrate that autologous cell transfer after lymphodepleting chemotherapy can cause the regression of large, vascularized tumors in patients with refractory metastatic melanoma. Eighteen of 35 patients treated with tumor-reactive lymphocyte cultures experienced an objec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-10, Vol.101 (Suppl 2), p.14639-14645
Hauptverfasser:	Rosenberg, Steven A., Dudley, Mark E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Antigens, Neoplasm Cancer Cells Cells, Cultured Chemotherapy Clinical trials Colloquium Papers Cultured tumor cells Female Humans Immunotherapy, Adoptive - methods Immunotherapy, Adoptive - trends In Vitro Techniques Lymphocyte Transfusion Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Male Melanoma Melanoma - immunology Melanoma - secondary Melanoma - therapy Middle Aged Patients Reactivity T lymphocytes Transplantation, Autologous Tumor cell line Tumors
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