Template-Assisted Filament Growth by Parallel Stacking of Tau

Tau Filaments are found in > 20 neurodegenerative diseases. Yet, because of their enormous molecular weights and poor tendency to form highly ordered 3D crystal lattices, they have evaded high-resolution structure determination. Here, we studied 25 derivatized tau mutants by using electron parama...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-07, Vol.101 (28), p.10278-10283
Hauptverfasser:	Margittai, Martin, Langen, Ralf, Prusiner, Stanley B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino Acid Sequence Amino acids Biochemistry Biological Sciences Biophysics Crystallization Electron Spin Resonance Spectroscopy Excimers Humans Hydrogen Bonding Line spectra Molecular Sequence Data Molecular structure Molecules Protein isoforms Protein Structure, Secondary Proteins Pyrenes - chemistry Spin exchange Spin labels tau Proteins - chemistry tau Proteins - genetics
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