Experimental stand for studying the impact of laser-accelerated protons on biological objects
An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to , the possibility is demo...
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| Veröffentlicht in: | Quantum electronics (Woodbury, N.Y.) N.Y.), 2016-01, Vol.46 (4), p.283-287 |
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| creator | Burdonov, K.F. Eremeev, A.A. Ignatova, N.I. Osmanov, R.R. Sladkov, A.D. Soloviev, A.A. Starodubtsev, M.V. Ginzburg, V.N. Kuzmin, A.A. Maslennikova, A.V. Revet, G. Sergeev, A.M. Fuchs, J. Khazanov, E.A. Chen, S. Shaykin, A.A. Shaikin, I.A. Yakovlev, I.V. |
| description | An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to , the possibility is demonstrated of transferring doses up to to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms. |
| doi_str_mv | 10.1070/QEL16043 |
| format | Article |
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In the course of pilot experiments with the energy of laser-accelerated protons up to , the possibility is demonstrated of transferring doses up to to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms.</description><identifier>ISSN: 1063-7818</identifier><identifier>EISSN: 1468-4799</identifier><identifier>DOI: 10.1070/QEL16043</identifier><language>eng</language><publisher>United States: Turpion Ltd and the Russian Academy of Sciences</publisher><subject>BIOLOGICAL RADIATION EFFECTS ; CELL CULTURES ; EXPERIMENT RESULTS ; Hadrons ; high-energy protons ; INTERACTIONS ; irradiation of cell cultures ; Laser plasma interactions ; LASER RADIATION ; laser-plasma interaction ; Lasers ; MEV RANGE ; NEOPLASMS ; PHYSICS OF ELEMENTARY PARTICLES AND FIELDS ; PLASMA ; PROTON BEAMS ; PROTONS ; RADIOLOGY AND NUCLEAR MEDICINE ; Separation ; Shot ; Stands ; Supports ; TAIL ELECTRONS ; THERAPEUTIC DOSES ; THERAPY ; X RADIATION</subject><ispartof>Quantum electronics (Woodbury, N.Y.), 2016-01, Vol.46 (4), p.283-287</ispartof><rights>2016 Kvantovaya Elektronika and Turpion Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-240805b9e63a956f550a2df7f3873ee50f9e119394e0846a23366070c02aa5833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1070/QEL16043/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>230,315,781,785,886,27929,27930,53851,53898</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22724638$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Burdonov, K.F.</creatorcontrib><creatorcontrib>Eremeev, A.A.</creatorcontrib><creatorcontrib>Ignatova, N.I.</creatorcontrib><creatorcontrib>Osmanov, R.R.</creatorcontrib><creatorcontrib>Sladkov, A.D.</creatorcontrib><creatorcontrib>Soloviev, A.A.</creatorcontrib><creatorcontrib>Starodubtsev, M.V.</creatorcontrib><creatorcontrib>Ginzburg, V.N.</creatorcontrib><creatorcontrib>Kuzmin, A.A.</creatorcontrib><creatorcontrib>Maslennikova, A.V.</creatorcontrib><creatorcontrib>Revet, G.</creatorcontrib><creatorcontrib>Sergeev, A.M.</creatorcontrib><creatorcontrib>Fuchs, J.</creatorcontrib><creatorcontrib>Khazanov, E.A.</creatorcontrib><creatorcontrib>Chen, S.</creatorcontrib><creatorcontrib>Shaykin, A.A.</creatorcontrib><creatorcontrib>Shaikin, I.A.</creatorcontrib><creatorcontrib>Yakovlev, I.V.</creatorcontrib><title>Experimental stand for studying the impact of laser-accelerated protons on biological objects</title><title>Quantum electronics (Woodbury, N.Y.)</title><addtitle>QEL</addtitle><addtitle>Quantum Electron</addtitle><description>An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to , the possibility is demonstrated of transferring doses up to to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms.</description><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>CELL CULTURES</subject><subject>EXPERIMENT RESULTS</subject><subject>Hadrons</subject><subject>high-energy protons</subject><subject>INTERACTIONS</subject><subject>irradiation of cell cultures</subject><subject>Laser plasma interactions</subject><subject>LASER RADIATION</subject><subject>laser-plasma interaction</subject><subject>Lasers</subject><subject>MEV RANGE</subject><subject>NEOPLASMS</subject><subject>PHYSICS OF ELEMENTARY PARTICLES AND FIELDS</subject><subject>PLASMA</subject><subject>PROTON BEAMS</subject><subject>PROTONS</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Separation</subject><subject>Shot</subject><subject>Stands</subject><subject>Supports</subject><subject>TAIL ELECTRONS</subject><subject>THERAPEUTIC DOSES</subject><subject>THERAPY</subject><subject>X RADIATION</subject><issn>1063-7818</issn><issn>1468-4799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLAzEUhQdRULTgTwjows1o3pNZitQHFETQpYQ0c9NGpsmYpKD_3kgVt67ugftxOOc0zSnBlwR3-OppviASc7bXHBEuVcu7vt-vGkvWdoqow2aWs19iwTkWSqqj5nX-MUHyGwjFjCgXEwbkYqpqO3z6sEJlDchvJmMLig6NJkNqjbUwQjIFBjSlWGLIKAa09HGMK2-rUVy-gS35pDlwZsww-7nHzcvt_Pnmvl083j3cXC9ay7gsLeVYYbHsQTLTC-mEwIYOrnNMdQxAYNcDIT3rOWDFpaGMSVn7WkyNEYqx4-Zs5xtz8TpbX8CubQyhhtCUdpRLpip1saNq5vct5KI3PtcmowkQt1kTRYVgCvP-D7Up5pzA6amOZNKnJlh_T61_p67o-Q71cdJvcZtCbfpfrL41l5prqpieBse-AKl1hwM</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Burdonov, K.F.</creator><creator>Eremeev, A.A.</creator><creator>Ignatova, N.I.</creator><creator>Osmanov, R.R.</creator><creator>Sladkov, A.D.</creator><creator>Soloviev, A.A.</creator><creator>Starodubtsev, M.V.</creator><creator>Ginzburg, V.N.</creator><creator>Kuzmin, A.A.</creator><creator>Maslennikova, A.V.</creator><creator>Revet, G.</creator><creator>Sergeev, A.M.</creator><creator>Fuchs, J.</creator><creator>Khazanov, E.A.</creator><creator>Chen, S.</creator><creator>Shaykin, A.A.</creator><creator>Shaikin, I.A.</creator><creator>Yakovlev, I.V.</creator><general>Turpion Ltd and the Russian Academy of Sciences</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>OTOTI</scope></search><sort><creationdate>20160101</creationdate><title>Experimental stand for studying the impact of laser-accelerated protons on biological objects</title><author>Burdonov, K.F. ; Eremeev, A.A. ; Ignatova, N.I. ; Osmanov, R.R. ; Sladkov, A.D. ; Soloviev, A.A. ; Starodubtsev, M.V. ; Ginzburg, V.N. ; Kuzmin, A.A. ; Maslennikova, A.V. ; Revet, G. ; Sergeev, A.M. ; Fuchs, J. ; Khazanov, E.A. ; Chen, S. ; Shaykin, A.A. ; Shaikin, I.A. ; Yakovlev, I.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-240805b9e63a956f550a2df7f3873ee50f9e119394e0846a23366070c02aa5833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>CELL CULTURES</topic><topic>EXPERIMENT RESULTS</topic><topic>Hadrons</topic><topic>high-energy protons</topic><topic>INTERACTIONS</topic><topic>irradiation of cell cultures</topic><topic>Laser plasma interactions</topic><topic>LASER RADIATION</topic><topic>laser-plasma interaction</topic><topic>Lasers</topic><topic>MEV RANGE</topic><topic>NEOPLASMS</topic><topic>PHYSICS OF ELEMENTARY PARTICLES AND FIELDS</topic><topic>PLASMA</topic><topic>PROTON BEAMS</topic><topic>PROTONS</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Separation</topic><topic>Shot</topic><topic>Stands</topic><topic>Supports</topic><topic>TAIL ELECTRONS</topic><topic>THERAPEUTIC DOSES</topic><topic>THERAPY</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burdonov, K.F.</creatorcontrib><creatorcontrib>Eremeev, A.A.</creatorcontrib><creatorcontrib>Ignatova, N.I.</creatorcontrib><creatorcontrib>Osmanov, R.R.</creatorcontrib><creatorcontrib>Sladkov, A.D.</creatorcontrib><creatorcontrib>Soloviev, A.A.</creatorcontrib><creatorcontrib>Starodubtsev, M.V.</creatorcontrib><creatorcontrib>Ginzburg, V.N.</creatorcontrib><creatorcontrib>Kuzmin, A.A.</creatorcontrib><creatorcontrib>Maslennikova, A.V.</creatorcontrib><creatorcontrib>Revet, G.</creatorcontrib><creatorcontrib>Sergeev, A.M.</creatorcontrib><creatorcontrib>Fuchs, J.</creatorcontrib><creatorcontrib>Khazanov, E.A.</creatorcontrib><creatorcontrib>Chen, S.</creatorcontrib><creatorcontrib>Shaykin, A.A.</creatorcontrib><creatorcontrib>Shaikin, I.A.</creatorcontrib><creatorcontrib>Yakovlev, I.V.</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>OSTI.GOV</collection><jtitle>Quantum electronics (Woodbury, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burdonov, K.F.</au><au>Eremeev, A.A.</au><au>Ignatova, N.I.</au><au>Osmanov, R.R.</au><au>Sladkov, A.D.</au><au>Soloviev, A.A.</au><au>Starodubtsev, M.V.</au><au>Ginzburg, V.N.</au><au>Kuzmin, A.A.</au><au>Maslennikova, A.V.</au><au>Revet, G.</au><au>Sergeev, A.M.</au><au>Fuchs, J.</au><au>Khazanov, E.A.</au><au>Chen, S.</au><au>Shaykin, A.A.</au><au>Shaikin, I.A.</au><au>Yakovlev, I.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental stand for studying the impact of laser-accelerated protons on biological objects</atitle><jtitle>Quantum electronics (Woodbury, N.Y.)</jtitle><stitle>QEL</stitle><addtitle>Quantum Electron</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>46</volume><issue>4</issue><spage>283</spage><epage>287</epage><pages>283-287</pages><issn>1063-7818</issn><eissn>1468-4799</eissn><abstract>An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to , the possibility is demonstrated of transferring doses up to to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms.</abstract><cop>United States</cop><pub>Turpion Ltd and the Russian Academy of Sciences</pub><doi>10.1070/QEL16043</doi><tpages>5</tpages></addata></record> |
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| ispartof | Quantum electronics (Woodbury, N.Y.), 2016-01, Vol.46 (4), p.283-287 |
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| source | IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | BIOLOGICAL RADIATION EFFECTS CELL CULTURES EXPERIMENT RESULTS Hadrons high-energy protons INTERACTIONS irradiation of cell cultures Laser plasma interactions LASER RADIATION laser-plasma interaction Lasers MEV RANGE NEOPLASMS PHYSICS OF ELEMENTARY PARTICLES AND FIELDS PLASMA PROTON BEAMS PROTONS RADIOLOGY AND NUCLEAR MEDICINE Separation Shot Stands Supports TAIL ELECTRONS THERAPEUTIC DOSES THERAPY X RADIATION |
| title | Experimental stand for studying the impact of laser-accelerated protons on biological objects |
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