One-step route to fluorinated furo[2,3- b]quinoxalines
The reaction of 6,7-difluoro-1-ethylquinoxalinium salts with 2,4-pentanedione, ethyl and bornyl acetoacetates and other β-keto esters results in the formation of 6,7-difluoro-3a,4,9,9a-tetrahydrofuro[2,3- b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino sub...
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| Veröffentlicht in: | Mendeleev communications 1998, Vol.8 (4), p.133-134 |
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| container_title | Mendeleev communications |
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| creator | Charushin, Valerii N. Mokrushina, Galina A. Petrova, Galina M. Alexandrov, Grigori G. Chupakhin, Oleg N. |
| description | The reaction of 6,7-difluoro-1-ethylquinoxalinium salts with 2,4-pentanedione, ethyl and bornyl acetoacetates and other β-keto esters results in the formation of 6,7-difluoro-3a,4,9,9a-tetrahydrofuro[2,3-
b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino substituted 1-ethylquinoxalinium salts react with alkyl acetoacetates in a regio- and stereoselective manner, thus giving exclusively the corresponding alkyl 2-methyl-6-fluoro-7-substituted 3a,4,9,9a-tetrahydrofuro[2,3-
b]quinoxalin-3-carboxylates. |
| doi_str_mv | 10.1070/MC1998v008n04ABEH000973 |
| format | Article |
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b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino substituted 1-ethylquinoxalinium salts react with alkyl acetoacetates in a regio- and stereoselective manner, thus giving exclusively the corresponding alkyl 2-methyl-6-fluoro-7-substituted 3a,4,9,9a-tetrahydrofuro[2,3-
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b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino substituted 1-ethylquinoxalinium salts react with alkyl acetoacetates in a regio- and stereoselective manner, thus giving exclusively the corresponding alkyl 2-methyl-6-fluoro-7-substituted 3a,4,9,9a-tetrahydrofuro[2,3-
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b]quinoxalines. In addition, asymmetric 6-fluoro-7-morpholino and 6-fluoro-7-thiomorpholino substituted 1-ethylquinoxalinium salts react with alkyl acetoacetates in a regio- and stereoselective manner, thus giving exclusively the corresponding alkyl 2-methyl-6-fluoro-7-substituted 3a,4,9,9a-tetrahydrofuro[2,3-
b]quinoxalin-3-carboxylates.</abstract><pub>Elsevier B.V</pub><doi>10.1070/MC1998v008n04ABEH000973</doi><tpages>2</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| title | One-step route to fluorinated furo[2,3- b]quinoxalines |
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