Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells

Background. High levels of glucose have previously been shown to inhibit endothelial cell migration and increase secretion of the von Willebrand factor (vWF), a marker of endothelial cell damage. This study investigates whether thiamine, an important coenzyme in intracellular glucose metabolism, imp...

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Veröffentlicht in:	Surgery 2001-11, Vol.130 (5), p.851-858
Hauptverfasser:	Ascher, Enrico, Gade, Prasad V., Hingorani, Anil, Puthukkeril, Silvy, Kallakuri, Sreedhar, Scheinman, Marcel, Jacob, Theresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cardiopathies: etiologic forms (general aspects and miscellaneous) Cattle Cell Count Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Diabetic Retinopathy - etiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Glucose - toxicity Heart Medical sciences Thiamine - pharmacology von Willebrand Factor - secretion
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