Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women
Objective: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. Study Design: Longitudinal uterine strips were used from the lower uterine...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2003-03, Vol.188 (3), p.774-778 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Bytautiene, Egle Vedernikov, Yuri P. Saade, George R. Romero, Roberto Garfield, Robert E. |
| description | Objective: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. Study Design: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10–8 to 10–4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (–)–indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. Results: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. Conclusion: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors. (Am J Obstet Gynecol 2003;188:774-8.) |
| doi_str_mv | 10.1067/mob.2003.162 |
| format | Article |
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Study Design: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10–8 to 10–4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (–)–indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. Results: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. Conclusion: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors. (Am J Obstet Gynecol 2003;188:774-8.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2003.162</identifier><identifier>PMID: 12634656</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Biological and medical sciences ; Chlorpheniramine - pharmacology ; Cimetidine - pharmacology ; contractility ; Dose-Response Relationship, Drug ; Female ; Genital system. Reproduction ; Histamine ; Histamine - administration & dosage ; Histamine - pharmacology ; Histamine H1 Antagonists - pharmacology ; Histamine H2 Antagonists - pharmacology ; histamine receptors ; human myometrium ; Humans ; Indoles - pharmacology ; Lactams - pharmacology ; Medical sciences ; Osmolar Concentration ; Pharmacology. Drug treatments ; pregnancy ; Pregnancy - physiology ; Uterine Contraction - drug effects ; Uterus - drug effects</subject><ispartof>American journal of obstetrics and gynecology, 2003-03, Vol.188 (3), p.774-778</ispartof><rights>2003 Mosby, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-a138cd57dc5955e199ab0c5514142cb50c827ebe70b8a22ad91573f397fa94023</citedby><cites>FETCH-LOGICAL-c364t-a138cd57dc5955e199ab0c5514142cb50c827ebe70b8a22ad91573f397fa94023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937802714920$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14660023$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12634656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bytautiene, Egle</creatorcontrib><creatorcontrib>Vedernikov, Yuri P.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><title>Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. Study Design: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10–8 to 10–4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (–)–indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. Results: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. Conclusion: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors. (Am J Obstet Gynecol 2003;188:774-8.)</description><subject>Biological and medical sciences</subject><subject>Chlorpheniramine - pharmacology</subject><subject>Cimetidine - pharmacology</subject><subject>contractility</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Histamine</subject><subject>Histamine - administration & dosage</subject><subject>Histamine - pharmacology</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Histamine H2 Antagonists - pharmacology</subject><subject>histamine receptors</subject><subject>human myometrium</subject><subject>Humans</subject><subject>Indoles - pharmacology</subject><subject>Lactams - pharmacology</subject><subject>Medical sciences</subject><subject>Osmolar Concentration</subject><subject>Pharmacology. Drug treatments</subject><subject>pregnancy</subject><subject>Pregnancy - physiology</subject><subject>Uterine Contraction - drug effects</subject><subject>Uterus - drug effects</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1LBCEYwHGJoratW-fw0q3ZfBmd8RjRGyx0qfPgOI9l7OigbtG3z2EXunRS4af4_BG6oGRFiWxuxtCvGCF8RSU7QAtKVFPJVraHaEEIYZXiTXuCTlP6nI9MsWN0QpnktRRygcy9tWAyDhZ_uJT16Dzg4PH0oZMzWPsB5-DLzgSfozbZBZ9m7VLY6AwD3maI86XsUtoCtjGMeIrw7rXP-DuM4M_QkdWbBOf7dYneHu5f756q9cvj893tujJc1rnSlLdmEM1ghBICqFK6J0YIWtOamV4Q07IGemhI32rG9KCoaLjlqrFa1YTxJbrevWtiSCmC7aboRh1_Okq6uVVXWnVzq660Kvxyx6dtP8Lwh_dxCrjaA52M3tiovXHpz9VSlqK8OLlzUIb7chC7ZBx4A4OLpW03BPf_D34BNKyFKQ</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Bytautiene, Egle</creator><creator>Vedernikov, Yuri P.</creator><creator>Saade, George R.</creator><creator>Romero, Roberto</creator><creator>Garfield, Robert E.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030301</creationdate><title>Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women</title><author>Bytautiene, Egle ; Vedernikov, Yuri P. ; Saade, George R. ; Romero, Roberto ; Garfield, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-a138cd57dc5955e199ab0c5514142cb50c827ebe70b8a22ad91573f397fa94023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Chlorpheniramine - pharmacology</topic><topic>Cimetidine - pharmacology</topic><topic>contractility</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Histamine</topic><topic>Histamine - administration & dosage</topic><topic>Histamine - pharmacology</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Histamine H2 Antagonists - pharmacology</topic><topic>histamine receptors</topic><topic>human myometrium</topic><topic>Humans</topic><topic>Indoles - pharmacology</topic><topic>Lactams - pharmacology</topic><topic>Medical sciences</topic><topic>Osmolar Concentration</topic><topic>Pharmacology. Drug treatments</topic><topic>pregnancy</topic><topic>Pregnancy - physiology</topic><topic>Uterine Contraction - drug effects</topic><topic>Uterus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bytautiene, Egle</creatorcontrib><creatorcontrib>Vedernikov, Yuri P.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bytautiene, Egle</au><au>Vedernikov, Yuri P.</au><au>Saade, George R.</au><au>Romero, Roberto</au><au>Garfield, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>188</volume><issue>3</issue><spage>774</spage><epage>778</epage><pages>774-778</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: To enhance our understanding of the uterotonic effect of histamine, we compared the effects of histamine on spontaneous phasic and tonic contractile activity of uterine strips from term pregnant nonlaboring women. Study Design: Longitudinal uterine strips were used from the lower uterine segment of term pregnant nonlaboring women undergoing elective cesarean section. The concentration-response relationship to histamine (10–8 to 10–4 mol/L) was determined in spontaneously contracting strips or in strips contracted tonically with a protein kinase C activator (–)–indolactam V in the presence of H1 receptor antagonist (S[+]-chlorpheniramine maleate), H2 receptor antagonist (cimetidine), or solvent. Results: Histamine increased spontaneous phasic myometrial contractions in a concentration-dependent manner. H1, but not H2, receptor antagonist significantly attenuated the response to histamine. Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect. Conclusion: Histamine increases spontaneous, but inhibits tonic, contractions of uterine strips from term pregnant nonlaboring women. Both effects are mediated through activation of H1 receptors. (Am J Obstet Gynecol 2003;188:774-8.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>12634656</pmid><doi>10.1067/mob.2003.162</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2003-03, Vol.188 (3), p.774-778 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Chlorpheniramine - pharmacology Cimetidine - pharmacology contractility Dose-Response Relationship, Drug Female Genital system. Reproduction Histamine Histamine - administration & dosage Histamine - pharmacology Histamine H1 Antagonists - pharmacology Histamine H2 Antagonists - pharmacology histamine receptors human myometrium Humans Indoles - pharmacology Lactams - pharmacology Medical sciences Osmolar Concentration Pharmacology. Drug treatments pregnancy Pregnancy - physiology Uterine Contraction - drug effects Uterus - drug effects |
| title | Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women |
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