Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease
Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involveme...
Gespeichert in:
| Veröffentlicht in: | The American heart journal 2001-02, Vol.141 (2), p.260-265 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 265 |
|---|---|
| container_issue | 2 |
| container_start_page | 260 |
| container_title | The American heart journal |
| container_volume | 141 |
| creator | Ribeiro, Antonio L.P. Moraes, Ruy S. Ribeiro, Jorge P. Ferlin, Elton L. Torres, Rosália M. Oliveira, Enilce Rocha, Manoel O.C. |
| description | Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involvement and healthy individuals by three different methods to determine whether vagal dysfunction is present in the early phase of Chagas disease. Methods Sixty-one patients with Chagas disease without cardiac involvement and 38 controls were submitted to respiratory sinus arrhythmia test and 24-hour Holter monitoring. Vagal heart influences were assessed by the expiratory/inspiratory (E/I) ratio, time-domain indexes of heart rate variability (HRV), and by the quantification of a 3-dimensional return map. Results The two groups were comparable in terms of left ventricular ejection fraction and left ventricular end-diastolic dimension. Compared with the control group, patients with Chagas disease had significantly lower values of the E/I ratio (mean ± SD: 1.38 ± 0.02 and 1.25 ± 0.02, P |
| doi_str_mv | 10.1067/mhj.2001.111406 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1067_mhj_2001_111406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000287030163552X</els_id><sourcerecordid>11174350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-782c741dc01c9759f86506a362678bd028803628faa2fb55765dc090660ae1ef3</originalsourceid><addsrcrecordid>eNp10EtLAzEQwPEgiq3VszdZ8LztZB9J9ijFFxT0oEdZptnEpuyLJFvYb2_KFj15CgO_CcmfkFsKSwqMr5rdfpkA0CWlNAN2RuYUCh4znmXnZA4ASSw4pDNy5dw-jCwR7JLMguZZmsOcfL2jRTc2Pfqd8kZG1ehw8F3bNQaj3iqpKuWiWmkfHVTrrZFDjTZyo_NdPXk9tNKbro1MG613-I0uqoxT6NQ1udBYO3VzOhfk8-nxY_0Sb96eX9cPm1imGfiYi0TyjFYSqCx4XmjBcmCYsoRxsa0gEQLCIDRiord5zlkebAGMASqqdLogq-leaTvnrNJlb02DdiwplMdQZQhVHkOVU6iwcTdt9MO2UdWfP5UJ4P4E0EmstcVWGvfrRJFBmgdVTEqF3x2MsqWTRrUhmgnpfFl15t8n_ACEjoTG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ribeiro, Antonio L.P. ; Moraes, Ruy S. ; Ribeiro, Jorge P. ; Ferlin, Elton L. ; Torres, Rosália M. ; Oliveira, Enilce ; Rocha, Manoel O.C.</creator><creatorcontrib>Ribeiro, Antonio L.P. ; Moraes, Ruy S. ; Ribeiro, Jorge P. ; Ferlin, Elton L. ; Torres, Rosália M. ; Oliveira, Enilce ; Rocha, Manoel O.C.</creatorcontrib><description>Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involvement and healthy individuals by three different methods to determine whether vagal dysfunction is present in the early phase of Chagas disease. Methods Sixty-one patients with Chagas disease without cardiac involvement and 38 controls were submitted to respiratory sinus arrhythmia test and 24-hour Holter monitoring. Vagal heart influences were assessed by the expiratory/inspiratory (E/I) ratio, time-domain indexes of heart rate variability (HRV), and by the quantification of a 3-dimensional return map. Results The two groups were comparable in terms of left ventricular ejection fraction and left ventricular end-diastolic dimension. Compared with the control group, patients with Chagas disease had significantly lower values of the E/I ratio (mean ± SD: 1.38 ± 0.02 and 1.25 ± 0.02, P <.004) and short-term indexes of HRV (median [interquartile range]—rMSSD: 23 [18-27] and 17 [13-23], P =.00; pNN50: 11 [7-17] and 6 [2-12], P =.00). P3, a beat-to-beat HRV index derived from the 3-dimensional return map, also was significantly reduced in the Chagas disease group (mean ± SD: 118 ± 5 vs 100 ± 4, P =.00). None of these indexes of vagal heart control were significantly correlated with left ventricular function or to the presence of esophageal radiologic abnormalities. Conclusion Parasympathetic dysautonomia is an independent and early phenomenon in Chagas disease and may precede left ventricular systolic dysfunction. (Am Heart J 2001;141:260-5.)</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1067/mhj.2001.111406</identifier><identifier>PMID: 11174350</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Biological and medical sciences ; Chagas Disease - complications ; Chagas Disease - physiopathology ; Circadian Rhythm ; Disease Progression ; Echocardiography, Doppler ; Electrocardiography, Ambulatory ; Female ; Heart Rate ; Heart Ventricles - innervation ; Heart Ventricles - physiopathology ; Human protozoal diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Parasitic diseases ; Protozoal diseases ; Stroke Volume ; Systole ; Trypanosomiasis ; Vagus Nerve - physiopathology ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>The American heart journal, 2001-02, Vol.141 (2), p.260-265</ispartof><rights>2001 Mosby, Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-782c741dc01c9759f86506a362678bd028803628faa2fb55765dc090660ae1ef3</citedby><cites>FETCH-LOGICAL-c340t-782c741dc01c9759f86506a362678bd028803628faa2fb55765dc090660ae1ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mhj.2001.111406$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=894035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11174350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, Antonio L.P.</creatorcontrib><creatorcontrib>Moraes, Ruy S.</creatorcontrib><creatorcontrib>Ribeiro, Jorge P.</creatorcontrib><creatorcontrib>Ferlin, Elton L.</creatorcontrib><creatorcontrib>Torres, Rosália M.</creatorcontrib><creatorcontrib>Oliveira, Enilce</creatorcontrib><creatorcontrib>Rocha, Manoel O.C.</creatorcontrib><title>Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involvement and healthy individuals by three different methods to determine whether vagal dysfunction is present in the early phase of Chagas disease. Methods Sixty-one patients with Chagas disease without cardiac involvement and 38 controls were submitted to respiratory sinus arrhythmia test and 24-hour Holter monitoring. Vagal heart influences were assessed by the expiratory/inspiratory (E/I) ratio, time-domain indexes of heart rate variability (HRV), and by the quantification of a 3-dimensional return map. Results The two groups were comparable in terms of left ventricular ejection fraction and left ventricular end-diastolic dimension. Compared with the control group, patients with Chagas disease had significantly lower values of the E/I ratio (mean ± SD: 1.38 ± 0.02 and 1.25 ± 0.02, P <.004) and short-term indexes of HRV (median [interquartile range]—rMSSD: 23 [18-27] and 17 [13-23], P =.00; pNN50: 11 [7-17] and 6 [2-12], P =.00). P3, a beat-to-beat HRV index derived from the 3-dimensional return map, also was significantly reduced in the Chagas disease group (mean ± SD: 118 ± 5 vs 100 ± 4, P =.00). None of these indexes of vagal heart control were significantly correlated with left ventricular function or to the presence of esophageal radiologic abnormalities. Conclusion Parasympathetic dysautonomia is an independent and early phenomenon in Chagas disease and may precede left ventricular systolic dysfunction. (Am Heart J 2001;141:260-5.)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chagas Disease - complications</subject><subject>Chagas Disease - physiopathology</subject><subject>Circadian Rhythm</subject><subject>Disease Progression</subject><subject>Echocardiography, Doppler</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Heart Ventricles - innervation</subject><subject>Heart Ventricles - physiopathology</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Stroke Volume</subject><subject>Systole</subject><subject>Trypanosomiasis</subject><subject>Vagus Nerve - physiopathology</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtLAzEQwPEgiq3VszdZ8LztZB9J9ijFFxT0oEdZptnEpuyLJFvYb2_KFj15CgO_CcmfkFsKSwqMr5rdfpkA0CWlNAN2RuYUCh4znmXnZA4ASSw4pDNy5dw-jCwR7JLMguZZmsOcfL2jRTc2Pfqd8kZG1ehw8F3bNQaj3iqpKuWiWmkfHVTrrZFDjTZyo_NdPXk9tNKbro1MG613-I0uqoxT6NQ1udBYO3VzOhfk8-nxY_0Sb96eX9cPm1imGfiYi0TyjFYSqCx4XmjBcmCYsoRxsa0gEQLCIDRiord5zlkebAGMASqqdLogq-leaTvnrNJlb02DdiwplMdQZQhVHkOVU6iwcTdt9MO2UdWfP5UJ4P4E0EmstcVWGvfrRJFBmgdVTEqF3x2MsqWTRrUhmgnpfFl15t8n_ACEjoTG</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Ribeiro, Antonio L.P.</creator><creator>Moraes, Ruy S.</creator><creator>Ribeiro, Jorge P.</creator><creator>Ferlin, Elton L.</creator><creator>Torres, Rosália M.</creator><creator>Oliveira, Enilce</creator><creator>Rocha, Manoel O.C.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010201</creationdate><title>Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease</title><author>Ribeiro, Antonio L.P. ; Moraes, Ruy S. ; Ribeiro, Jorge P. ; Ferlin, Elton L. ; Torres, Rosália M. ; Oliveira, Enilce ; Rocha, Manoel O.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-782c741dc01c9759f86506a362678bd028803628faa2fb55765dc090660ae1ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chagas Disease - complications</topic><topic>Chagas Disease - physiopathology</topic><topic>Circadian Rhythm</topic><topic>Disease Progression</topic><topic>Echocardiography, Doppler</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Heart Ventricles - innervation</topic><topic>Heart Ventricles - physiopathology</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Stroke Volume</topic><topic>Systole</topic><topic>Trypanosomiasis</topic><topic>Vagus Nerve - physiopathology</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, Antonio L.P.</creatorcontrib><creatorcontrib>Moraes, Ruy S.</creatorcontrib><creatorcontrib>Ribeiro, Jorge P.</creatorcontrib><creatorcontrib>Ferlin, Elton L.</creatorcontrib><creatorcontrib>Torres, Rosália M.</creatorcontrib><creatorcontrib>Oliveira, Enilce</creatorcontrib><creatorcontrib>Rocha, Manoel O.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, Antonio L.P.</au><au>Moraes, Ruy S.</au><au>Ribeiro, Jorge P.</au><au>Ferlin, Elton L.</au><au>Torres, Rosália M.</au><au>Oliveira, Enilce</au><au>Rocha, Manoel O.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>141</volume><issue>2</issue><spage>260</spage><epage>265</epage><pages>260-265</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Parasympathetic dysautonomia is an established feature of advanced Chagas cardiomyopathy. However, in the absence of cardiac involvement, the presence of vagal dysfunction remains controversial. In a cross-sectional study, we compared patients with Chagas disease without cardiac involvement and healthy individuals by three different methods to determine whether vagal dysfunction is present in the early phase of Chagas disease. Methods Sixty-one patients with Chagas disease without cardiac involvement and 38 controls were submitted to respiratory sinus arrhythmia test and 24-hour Holter monitoring. Vagal heart influences were assessed by the expiratory/inspiratory (E/I) ratio, time-domain indexes of heart rate variability (HRV), and by the quantification of a 3-dimensional return map. Results The two groups were comparable in terms of left ventricular ejection fraction and left ventricular end-diastolic dimension. Compared with the control group, patients with Chagas disease had significantly lower values of the E/I ratio (mean ± SD: 1.38 ± 0.02 and 1.25 ± 0.02, P <.004) and short-term indexes of HRV (median [interquartile range]—rMSSD: 23 [18-27] and 17 [13-23], P =.00; pNN50: 11 [7-17] and 6 [2-12], P =.00). P3, a beat-to-beat HRV index derived from the 3-dimensional return map, also was significantly reduced in the Chagas disease group (mean ± SD: 118 ± 5 vs 100 ± 4, P =.00). None of these indexes of vagal heart control were significantly correlated with left ventricular function or to the presence of esophageal radiologic abnormalities. Conclusion Parasympathetic dysautonomia is an independent and early phenomenon in Chagas disease and may precede left ventricular systolic dysfunction. (Am Heart J 2001;141:260-5.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11174350</pmid><doi>10.1067/mhj.2001.111406</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 2001-02, Vol.141 (2), p.260-265 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_crossref_primary_10_1067_mhj_2001_111406 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Biological and medical sciences Chagas Disease - complications Chagas Disease - physiopathology Circadian Rhythm Disease Progression Echocardiography, Doppler Electrocardiography, Ambulatory Female Heart Rate Heart Ventricles - innervation Heart Ventricles - physiopathology Human protozoal diseases Humans Infectious diseases Male Medical sciences Middle Aged Parasitic diseases Protozoal diseases Stroke Volume Systole Trypanosomiasis Vagus Nerve - physiopathology Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T15%3A31%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parasympathetic%20dysautonomia%20precedes%20left%20ventricular%20systolic%20dysfunction%20in%20Chagas%20disease&rft.jtitle=The%20American%20heart%20journal&rft.au=Ribeiro,%20Antonio%20L.P.&rft.date=2001-02-01&rft.volume=141&rft.issue=2&rft.spage=260&rft.epage=265&rft.pages=260-265&rft.issn=0002-8703&rft.eissn=1097-6744&rft.coden=AHJOA2&rft_id=info:doi/10.1067/mhj.2001.111406&rft_dat=%3Cpubmed_cross%3E11174350%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11174350&rft_els_id=S000287030163552X&rfr_iscdi=true |