Lowering of acoustic droplet vaporization threshold via aggregation

Acoustically sensitive emulsion nanodroplets composed of perfluorocarbon have shown great potential for advanced medical diagnosis and therapy but are limited by the required high acoustic droplet vaporization (ADV) threshold for clinical applications. This study investigates the use of an ultrasoni...

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Veröffentlicht in:Applied physics letters 2017-12, Vol.111 (25)
Hauptverfasser: Guo, Shifang, Shi, Aiwei, Xu, Shanshan, Du, Xuan, Wang, Xin, Zong, Yujin, Bouakaz, Ayache, Wan, Mingxi
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container_issue 25
container_start_page
container_title Applied physics letters
container_volume 111
creator Guo, Shifang
Shi, Aiwei
Xu, Shanshan
Du, Xuan
Wang, Xin
Zong, Yujin
Bouakaz, Ayache
Wan, Mingxi
description Acoustically sensitive emulsion nanodroplets composed of perfluorocarbon have shown great potential for advanced medical diagnosis and therapy but are limited by the required high acoustic droplet vaporization (ADV) threshold for clinical applications. This study investigates the use of an ultrasonic standing wave to lower the ADV threshold while maintaining the generated bubble size in the required size range, ensuring the generation of inertial cavitation and corresponding physical effects. The results showed that disperse nanodroplets were manipulated to form micron-sized aggregations, and the required ADV threshold was significantly lowered, while a similar size range of the microbubbles generated by disperse nanodroplets was maintained. The threshold could be further regulated by adjusting the aggregation size via controlling the concentration of the disperse nanodroplets. Furthermore, the internal pressures in the aggregations with different sizes were calculated to determine their ADV thresholds theoretically, which were shown to be in good agreement with the experimental results.
doi_str_mv 10.1063/1.5005957
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subjects Agglomeration
Applied physics
Cavitation
Droplets
Perfluorocarbons
Standing waves
Vaporization
title Lowering of acoustic droplet vaporization threshold via aggregation
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