Microfluidic electrical sorting of particles based on shape in a spiral microchannel
Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We...
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| Veröffentlicht in: | Biomicrofluidics 2014-01, Vol.8 (1), p.014101-014101 |
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| container_title | Biomicrofluidics |
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| creator | DuBose, John Lu, Xinyu Patel, Saurin Qian, Shizhi Woo Joo, Sang Xuan, Xiangchun |
| description | Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation. |
| doi_str_mv | 10.1063/1.4862355 |
| format | Article |
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The predicted particle trajectories agree qualitatively with the experimental observation.</description><subject>Cell cycle</subject><subject>Computer simulation</subject><subject>Curvature</subject><subject>Dielectrophoresis</subject><subject>Flow paths</subject><subject>Mathematical models</subject><subject>Microchannels</subject><subject>Organic chemistry</subject><subject>Particle sorting</subject><subject>Particle trajectories</subject><subject>Regular</subject><subject>Sheaths</subject><issn>1932-1058</issn><issn>1932-1058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LHTEYhUOpqFUX_QMl0E0tXDtJJh-zEYrYWlC60XXIJG-8kbnJNJkR-u-by71-Ql3lQB5OTs5B6CNpTkgj2Ddy0ipBGefv0D7pGF2Qhqv3z_Qe-lDKXdNwIindRXu0lZxVuY-ur4LNyQ9zcMFiGMBOOVgz4JLyFOItTh6Ppko7QMG9KeBwirgszQg4RGxwGUOu_GrtY5cmRhgO0Y43Q4Gj7XmAbn6cX59dLC5___x19v1yYTnrpoWXohemY21vG-udoqZtu164VlIJVinuwFDHGfOKGEqV5AKEV84BCCMJYQfodOM7zv0KnIU41Sh6zGFl8l-dTNAvb2JY6tt0r1knpexUNfiyNcjpzwxl0qtQLAyDiZDmogkntdja8fqtz6_QuzTnWL-nKaFSioaorlLHG6qWUUoG_xiGNHq9lSZ6u1VlPz1P_0g-jFOBrxug2DCZKaT4ptt_4fuUn0A9Os_-AZjWq6g</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>DuBose, John</creator><creator>Lu, Xinyu</creator><creator>Patel, Saurin</creator><creator>Qian, Shizhi</creator><creator>Woo Joo, Sang</creator><creator>Xuan, Xiangchun</creator><general>American Institute of Physics</general><general>AIP Publishing LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Microfluidic electrical sorting of particles based on shape in a spiral microchannel</title><author>DuBose, John ; Lu, Xinyu ; Patel, Saurin ; Qian, Shizhi ; Woo Joo, Sang ; Xuan, Xiangchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-f76b6a934bc0cfd82a449b6d4727ec885dea2d533f81a228756e6f8ddee6a7113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cell cycle</topic><topic>Computer simulation</topic><topic>Curvature</topic><topic>Dielectrophoresis</topic><topic>Flow paths</topic><topic>Mathematical models</topic><topic>Microchannels</topic><topic>Organic chemistry</topic><topic>Particle sorting</topic><topic>Particle trajectories</topic><topic>Regular</topic><topic>Sheaths</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DuBose, John</creatorcontrib><creatorcontrib>Lu, Xinyu</creatorcontrib><creatorcontrib>Patel, Saurin</creatorcontrib><creatorcontrib>Qian, Shizhi</creatorcontrib><creatorcontrib>Woo Joo, Sang</creatorcontrib><creatorcontrib>Xuan, Xiangchun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomicrofluidics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DuBose, John</au><au>Lu, Xinyu</au><au>Patel, Saurin</au><au>Qian, Shizhi</au><au>Woo Joo, Sang</au><au>Xuan, Xiangchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microfluidic electrical sorting of particles based on shape in a spiral microchannel</atitle><jtitle>Biomicrofluidics</jtitle><addtitle>Biomicrofluidics</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>8</volume><issue>1</issue><spage>014101</spage><epage>014101</epage><pages>014101-014101</pages><issn>1932-1058</issn><eissn>1932-1058</eissn><coden>BIOMGB</coden><abstract>Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. 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| source | American Institute of Physics; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cell cycle Computer simulation Curvature Dielectrophoresis Flow paths Mathematical models Microchannels Organic chemistry Particle sorting Particle trajectories Regular Sheaths |
| title | Microfluidic electrical sorting of particles based on shape in a spiral microchannel |
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