Size-dependent DNA mobility in nanochannels
Nanofluidic slits are used to investigate surface interactions during electrophoresis between DNA molecules and channel walls. The channels have vertical dimensions of 19 and 70 nm and contain no sieving matrix. Size-dependent mobility is observed for DNA in the 19 nm channels. We present a model fo...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physics 2007-07, Vol.102 (2), p.024701-024701-5 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 024701-5 |
|---|---|
| container_issue | 2 |
| container_start_page | 024701 |
| container_title | Journal of applied physics |
| container_volume | 102 |
| creator | Cross, Joshua David Strychalski, Elizabeth A. Craighead, H. G. |
| description | Nanofluidic slits are used to investigate surface interactions during electrophoresis between DNA molecules and channel walls. The channels have vertical dimensions of 19 and
70
nm
and contain no sieving matrix. Size-dependent mobility is observed for DNA in the
19
nm
channels. We present a model for double stranded DNA mobility in the nanochannels that accurately predicts the size dependence of the DNA mobility in the range of
2000
-
10
000
bp
. Due to surface interactions, the DNA mobility in the nanochannels scales as
N
−
1
∕
2
. These results suggest that the notion of free solution DNA electrophoresis breaks down due to surface interactions in nanoscale environments. |
| doi_str_mv | 10.1063/1.2757202 |
| format | Article |
| fullrecord | <record><control><sourceid>scitation_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1063_1_2757202</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>jap</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-69b3c89aa1227d5c6208e5b1095d0a3488ed2efe7e88abc780ac6f0020493d563</originalsourceid><addsrcrecordid>eNp1z09LwzAYx_EgCtbpwXfQq0jmk2Rpkosw5vwDQw_qOaTJU4y06Wh6ma_ejg1vnp7Ll4ffh5BrBnMGlbhjc66k4sBPSMFAG6qkhFNSAHBGtVHmnFzk_A3AmBamILfv8QdpwC2mgGksH16XZdfXsY3jroypTC71_sulhG2-JGeNazNeHe-MfD6uP1bPdPP29LJabqgXEkZamVp4bZxjnKsgfcVBo6wZGBnAiYXWGDg2qFBrV3ulwfmqmQbCwoggKzEjN4e_fuhzHrCx2yF2bthZBnavtMwelVN7f2izj6MbY5_-j_dU-0e1E9V24hdZzlfb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Size-dependent DNA mobility in nanochannels</title><source>AIP Journals Complete</source><source>AIP Digital Archive</source><creator>Cross, Joshua David ; Strychalski, Elizabeth A. ; Craighead, H. G.</creator><creatorcontrib>Cross, Joshua David ; Strychalski, Elizabeth A. ; Craighead, H. G.</creatorcontrib><description>Nanofluidic slits are used to investigate surface interactions during electrophoresis between DNA molecules and channel walls. The channels have vertical dimensions of 19 and
70
nm
and contain no sieving matrix. Size-dependent mobility is observed for DNA in the
19
nm
channels. We present a model for double stranded DNA mobility in the nanochannels that accurately predicts the size dependence of the DNA mobility in the range of
2000
-
10
000
bp
. Due to surface interactions, the DNA mobility in the nanochannels scales as
N
−
1
∕
2
. These results suggest that the notion of free solution DNA electrophoresis breaks down due to surface interactions in nanoscale environments.</description><identifier>ISSN: 0021-8979</identifier><identifier>EISSN: 1089-7550</identifier><identifier>DOI: 10.1063/1.2757202</identifier><identifier>CODEN: JAPIAU</identifier><language>eng</language><publisher>American Institute of Physics</publisher><ispartof>Journal of applied physics, 2007-07, Vol.102 (2), p.024701-024701-5</ispartof><rights>2007 American Institute of Physics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-69b3c89aa1227d5c6208e5b1095d0a3488ed2efe7e88abc780ac6f0020493d563</citedby><cites>FETCH-LOGICAL-c350t-69b3c89aa1227d5c6208e5b1095d0a3488ed2efe7e88abc780ac6f0020493d563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/jap/article-lookup/doi/10.1063/1.2757202$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>314,780,784,794,1559,4512,27924,27925,76384,76390</link.rule.ids></links><search><creatorcontrib>Cross, Joshua David</creatorcontrib><creatorcontrib>Strychalski, Elizabeth A.</creatorcontrib><creatorcontrib>Craighead, H. G.</creatorcontrib><title>Size-dependent DNA mobility in nanochannels</title><title>Journal of applied physics</title><description>Nanofluidic slits are used to investigate surface interactions during electrophoresis between DNA molecules and channel walls. The channels have vertical dimensions of 19 and
70
nm
and contain no sieving matrix. Size-dependent mobility is observed for DNA in the
19
nm
channels. We present a model for double stranded DNA mobility in the nanochannels that accurately predicts the size dependence of the DNA mobility in the range of
2000
-
10
000
bp
. Due to surface interactions, the DNA mobility in the nanochannels scales as
N
−
1
∕
2
. These results suggest that the notion of free solution DNA electrophoresis breaks down due to surface interactions in nanoscale environments.</description><issn>0021-8979</issn><issn>1089-7550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp1z09LwzAYx_EgCtbpwXfQq0jmk2Rpkosw5vwDQw_qOaTJU4y06Wh6ma_ejg1vnp7Ll4ffh5BrBnMGlbhjc66k4sBPSMFAG6qkhFNSAHBGtVHmnFzk_A3AmBamILfv8QdpwC2mgGksH16XZdfXsY3jroypTC71_sulhG2-JGeNazNeHe-MfD6uP1bPdPP29LJabqgXEkZamVp4bZxjnKsgfcVBo6wZGBnAiYXWGDg2qFBrV3ulwfmqmQbCwoggKzEjN4e_fuhzHrCx2yF2bthZBnavtMwelVN7f2izj6MbY5_-j_dU-0e1E9V24hdZzlfb</recordid><startdate>20070715</startdate><enddate>20070715</enddate><creator>Cross, Joshua David</creator><creator>Strychalski, Elizabeth A.</creator><creator>Craighead, H. G.</creator><general>American Institute of Physics</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20070715</creationdate><title>Size-dependent DNA mobility in nanochannels</title><author>Cross, Joshua David ; Strychalski, Elizabeth A. ; Craighead, H. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-69b3c89aa1227d5c6208e5b1095d0a3488ed2efe7e88abc780ac6f0020493d563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cross, Joshua David</creatorcontrib><creatorcontrib>Strychalski, Elizabeth A.</creatorcontrib><creatorcontrib>Craighead, H. G.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of applied physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cross, Joshua David</au><au>Strychalski, Elizabeth A.</au><au>Craighead, H. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Size-dependent DNA mobility in nanochannels</atitle><jtitle>Journal of applied physics</jtitle><date>2007-07-15</date><risdate>2007</risdate><volume>102</volume><issue>2</issue><spage>024701</spage><epage>024701-5</epage><pages>024701-024701-5</pages><issn>0021-8979</issn><eissn>1089-7550</eissn><coden>JAPIAU</coden><abstract>Nanofluidic slits are used to investigate surface interactions during electrophoresis between DNA molecules and channel walls. The channels have vertical dimensions of 19 and
70
nm
and contain no sieving matrix. Size-dependent mobility is observed for DNA in the
19
nm
channels. We present a model for double stranded DNA mobility in the nanochannels that accurately predicts the size dependence of the DNA mobility in the range of
2000
-
10
000
bp
. Due to surface interactions, the DNA mobility in the nanochannels scales as
N
−
1
∕
2
. These results suggest that the notion of free solution DNA electrophoresis breaks down due to surface interactions in nanoscale environments.</abstract><pub>American Institute of Physics</pub><doi>10.1063/1.2757202</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8979 |
| ispartof | Journal of applied physics, 2007-07, Vol.102 (2), p.024701-024701-5 |
| issn | 0021-8979 1089-7550 |
| language | eng |
| recordid | cdi_crossref_primary_10_1063_1_2757202 |
| source | AIP Journals Complete; AIP Digital Archive |
| title | Size-dependent DNA mobility in nanochannels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A10%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scitation_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Size-dependent%20DNA%20mobility%20in%20nanochannels&rft.jtitle=Journal%20of%20applied%20physics&rft.au=Cross,%20Joshua%20David&rft.date=2007-07-15&rft.volume=102&rft.issue=2&rft.spage=024701&rft.epage=024701-5&rft.pages=024701-024701-5&rft.issn=0021-8979&rft.eissn=1089-7550&rft.coden=JAPIAU&rft_id=info:doi/10.1063/1.2757202&rft_dat=%3Cscitation_cross%3Ejap%3C/scitation_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |