Optical observation of contrast agent destruction

Optical observation of contrast agent destruction

Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during co...

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Veröffentlicht in:Applied physics letters 2000-08, Vol.77 (7), p.1056-1058
Hauptverfasser: Chomas, James E., Dayton, Paul A., May, Donovan, Allen, John, Klibanov, Alexander, Ferrara, Katherine
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container_end_page 1058
container_issue 7
container_start_page 1056
container_title Applied physics letters
container_volume 77
creator Chomas, James E.
Dayton, Paul A.
May, Donovan
Allen, John
Klibanov, Alexander
Ferrara, Katherine
description Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of −700 m/s and peak acceleration of 1.2×1012 m/s2 is observed for insonation with a peak pressure of −1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh–Plesset model predict a peak negative wall velocity of −680 m/s and peak acceleration of 2×1012 m/s2.
doi_str_mv 10.1063/1.1287519
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title Optical observation of contrast agent destruction
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