Severe Covid-19
Patients with severe Covid-19 should have close monitoring for the need for endotracheal intubation; intubated patients should receive lung-protective ventilation. Data from randomized, controlled trials support a reduction in mortality with the use of dexamethasone and a reduction in time to clinic...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2020-12, Vol.383 (25), p.2451-2460 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2460 |
|---|---|
| container_issue | 25 |
| container_start_page | 2451 |
| container_title | The New England journal of medicine |
| container_volume | 383 |
| creator | Berlin, David A Gulick, Roy M Martinez, Fernando J |
| description | Patients with severe Covid-19 should have close monitoring for the need for endotracheal intubation; intubated patients should receive lung-protective ventilation. Data from randomized, controlled trials support a reduction in mortality with the use of dexamethasone and a reduction in time to clinical recovery with the use of remdesivir. |
| doi_str_mv | 10.1056/NEJMcp2009575 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1056_NEJMcp2009575</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2470668590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-eeef31a2d2ba1727a155072e9d162c482d888ac826bff89b400c42bdb9503fee3</originalsourceid><addsrcrecordid>eNqN0E1LxDAQBuAgiruu4smrCOJJqpNpkibHpaxfrHpQz6VNp9DFtmvTrvjvzdJ1wYNgLnN5ZibvMHbC4YqDVNdPs4dHu0QAIyO5w8ZchmEgBKhdNgZAHYjIhCN24NwC_OPC7LNRiIJjxGHMjl9oRS2dxc2qzANuDtlekb47OtrUCXu7mb3Gd8H8-fY-ns4DKxR2AREVIU8xxyzlEUYplxIiJJNzhVZozLXWqdWosqLQJhMAVmCWZ0ZCWBCFE3Y-zF22zUdPrksWTd_WfmWCIgKltDTgVTAo2zbOtVQky7as0vYr4ZCs4ye_4nt_upnaZxXlW_2T14PLAXxS1hTOllRb2jJ_H7U-kZe-oNf6_zouu7Qrmzpu-rrzrRdDa1W5pKZF9cePvwFHyn3J</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2470668590</pqid></control><display><type>article</type><title>Severe Covid-19</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>New England Journal of Medicine</source><creator>Berlin, David A ; Gulick, Roy M ; Martinez, Fernando J</creator><contributor>Solomon, Caren G ; Solomon, Caren G.</contributor><creatorcontrib>Berlin, David A ; Gulick, Roy M ; Martinez, Fernando J ; Solomon, Caren G ; Solomon, Caren G.</creatorcontrib><description>Patients with severe Covid-19 should have close monitoring for the need for endotracheal intubation; intubated patients should receive lung-protective ventilation. Data from randomized, controlled trials support a reduction in mortality with the use of dexamethasone and a reduction in time to clinical recovery with the use of remdesivir.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMcp2009575</identifier><identifier>PMID: 32412710</identifier><language>eng</language><publisher>WALTHAM: Massachusetts Medical Society</publisher><subject><![CDATA[Adenosine Monophosphate - analogs & derivatives ; Adenosine Monophosphate - therapeutic use ; Alanine - analogs & derivatives ; Alanine - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Antiviral Agents - therapeutic use ; Antiviral drugs ; Brain - diagnostic imaging ; Clinical trials ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - diagnosis ; COVID-19 - therapy ; COVID-19 Testing ; Dexamethasone ; Dexamethasone - therapeutic use ; Dyspnea ; Dyspnea - etiology ; Edema ; Failure ; General & Internal Medicine ; Humans ; Hypoxemia ; Illnesses ; Infections ; Intubation ; Life Sciences & Biomedicine ; Lung - diagnostic imaging ; Lung - pathology ; Male ; Masks ; Mechanical ventilation ; Medical supplies ; Medicine, General & Internal ; Middle Aged ; Oxygen saturation ; Pandemics ; Patient Acuity ; Patients ; Personal protective equipment ; Radiography, Thoracic ; Renal failure ; Respiration, Artificial ; Respiratory distress syndrome ; Respiratory Distress Syndrome - etiology ; Respiratory Distress Syndrome - therapy ; SARS-CoV-2 - genetics ; SARS-CoV-2 - isolation & purification ; Science & Technology ; Severe acute respiratory syndrome coronavirus 2 ; Thrombosis ; Tomography, X-Ray Computed ; Ventilators]]></subject><ispartof>The New England journal of medicine, 2020-12, Vol.383 (25), p.2451-2460</ispartof><rights>Copyright © 2020 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>990</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000600147100012</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c462t-eeef31a2d2ba1727a155072e9d162c482d888ac826bff89b400c42bdb9503fee3</citedby><cites>FETCH-LOGICAL-c462t-eeef31a2d2ba1727a155072e9d162c482d888ac826bff89b400c42bdb9503fee3</cites><orcidid>0000-0002-1431-8912 ; 0000-0002-7397-8945</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMcp2009575$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2470668590?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,2763,2764,26112,27933,27934,28257,52391,54073,64394,64398,72478</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32412710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Solomon, Caren G</contributor><contributor>Solomon, Caren G.</contributor><creatorcontrib>Berlin, David A</creatorcontrib><creatorcontrib>Gulick, Roy M</creatorcontrib><creatorcontrib>Martinez, Fernando J</creatorcontrib><title>Severe Covid-19</title><title>The New England journal of medicine</title><addtitle>NEW ENGL J MED</addtitle><addtitle>N Engl J Med</addtitle><description>Patients with severe Covid-19 should have close monitoring for the need for endotracheal intubation; intubated patients should receive lung-protective ventilation. Data from randomized, controlled trials support a reduction in mortality with the use of dexamethasone and a reduction in time to clinical recovery with the use of remdesivir.</description><subject>Adenosine Monophosphate - analogs & derivatives</subject><subject>Adenosine Monophosphate - therapeutic use</subject><subject>Alanine - analogs & derivatives</subject><subject>Alanine - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antiviral drugs</subject><subject>Brain - diagnostic imaging</subject><subject>Clinical trials</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - therapy</subject><subject>COVID-19 Testing</subject><subject>Dexamethasone</subject><subject>Dexamethasone - therapeutic use</subject><subject>Dyspnea</subject><subject>Dyspnea - etiology</subject><subject>Edema</subject><subject>Failure</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Hypoxemia</subject><subject>Illnesses</subject><subject>Infections</subject><subject>Intubation</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Masks</subject><subject>Mechanical ventilation</subject><subject>Medical supplies</subject><subject>Medicine, General & Internal</subject><subject>Middle Aged</subject><subject>Oxygen saturation</subject><subject>Pandemics</subject><subject>Patient Acuity</subject><subject>Patients</subject><subject>Personal protective equipment</subject><subject>Radiography, Thoracic</subject><subject>Renal failure</subject><subject>Respiration, Artificial</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome - etiology</subject><subject>Respiratory Distress Syndrome - therapy</subject><subject>SARS-CoV-2 - genetics</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Science & Technology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Thrombosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Ventilators</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0E1LxDAQBuAgiruu4smrCOJJqpNpkibHpaxfrHpQz6VNp9DFtmvTrvjvzdJ1wYNgLnN5ZibvMHbC4YqDVNdPs4dHu0QAIyO5w8ZchmEgBKhdNgZAHYjIhCN24NwC_OPC7LNRiIJjxGHMjl9oRS2dxc2qzANuDtlekb47OtrUCXu7mb3Gd8H8-fY-ns4DKxR2AREVIU8xxyzlEUYplxIiJJNzhVZozLXWqdWosqLQJhMAVmCWZ0ZCWBCFE3Y-zF22zUdPrksWTd_WfmWCIgKltDTgVTAo2zbOtVQky7as0vYr4ZCs4ye_4nt_upnaZxXlW_2T14PLAXxS1hTOllRb2jJ_H7U-kZe-oNf6_zouu7Qrmzpu-rrzrRdDa1W5pKZF9cePvwFHyn3J</recordid><startdate>20201217</startdate><enddate>20201217</enddate><creator>Berlin, David A</creator><creator>Gulick, Roy M</creator><creator>Martinez, Fernando J</creator><general>Massachusetts Medical Society</general><general>Massachusetts Medical Soc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-1431-8912</orcidid><orcidid>https://orcid.org/0000-0002-7397-8945</orcidid></search><sort><creationdate>20201217</creationdate><title>Severe Covid-19</title><author>Berlin, David A ; Gulick, Roy M ; Martinez, Fernando J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-eeef31a2d2ba1727a155072e9d162c482d888ac826bff89b400c42bdb9503fee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenosine Monophosphate - analogs & derivatives</topic><topic>Adenosine Monophosphate - therapeutic use</topic><topic>Alanine - analogs & derivatives</topic><topic>Alanine - therapeutic use</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Antiviral drugs</topic><topic>Brain - diagnostic imaging</topic><topic>Clinical trials</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - therapy</topic><topic>COVID-19 Testing</topic><topic>Dexamethasone</topic><topic>Dexamethasone - therapeutic use</topic><topic>Dyspnea</topic><topic>Dyspnea - etiology</topic><topic>Edema</topic><topic>Failure</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Hypoxemia</topic><topic>Illnesses</topic><topic>Infections</topic><topic>Intubation</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Masks</topic><topic>Mechanical ventilation</topic><topic>Medical supplies</topic><topic>Medicine, General & Internal</topic><topic>Middle Aged</topic><topic>Oxygen saturation</topic><topic>Pandemics</topic><topic>Patient Acuity</topic><topic>Patients</topic><topic>Personal protective equipment</topic><topic>Radiography, Thoracic</topic><topic>Renal failure</topic><topic>Respiration, Artificial</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome - etiology</topic><topic>Respiratory Distress Syndrome - therapy</topic><topic>SARS-CoV-2 - genetics</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Science & Technology</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Thrombosis</topic><topic>Tomography, X-Ray Computed</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlin, David A</creatorcontrib><creatorcontrib>Gulick, Roy M</creatorcontrib><creatorcontrib>Martinez, Fernando J</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlin, David A</au><au>Gulick, Roy M</au><au>Martinez, Fernando J</au><au>Solomon, Caren G</au><au>Solomon, Caren G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe Covid-19</atitle><jtitle>The New England journal of medicine</jtitle><stitle>NEW ENGL J MED</stitle><addtitle>N Engl J Med</addtitle><date>2020-12-17</date><risdate>2020</risdate><volume>383</volume><issue>25</issue><spage>2451</spage><epage>2460</epage><pages>2451-2460</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Patients with severe Covid-19 should have close monitoring for the need for endotracheal intubation; intubated patients should receive lung-protective ventilation. Data from randomized, controlled trials support a reduction in mortality with the use of dexamethasone and a reduction in time to clinical recovery with the use of remdesivir.</abstract><cop>WALTHAM</cop><pub>Massachusetts Medical Society</pub><pmid>32412710</pmid><doi>10.1056/NEJMcp2009575</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1431-8912</orcidid><orcidid>https://orcid.org/0000-0002-7397-8945</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2020-12, Vol.383 (25), p.2451-2460 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_crossref_primary_10_1056_NEJMcp2009575 |
| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - therapeutic use Alanine - analogs & derivatives Alanine - therapeutic use Anti-Inflammatory Agents - therapeutic use Antiviral Agents - therapeutic use Antiviral drugs Brain - diagnostic imaging Clinical trials Coronaviruses COVID-19 COVID-19 - complications COVID-19 - diagnosis COVID-19 - therapy COVID-19 Testing Dexamethasone Dexamethasone - therapeutic use Dyspnea Dyspnea - etiology Edema Failure General & Internal Medicine Humans Hypoxemia Illnesses Infections Intubation Life Sciences & Biomedicine Lung - diagnostic imaging Lung - pathology Male Masks Mechanical ventilation Medical supplies Medicine, General & Internal Middle Aged Oxygen saturation Pandemics Patient Acuity Patients Personal protective equipment Radiography, Thoracic Renal failure Respiration, Artificial Respiratory distress syndrome Respiratory Distress Syndrome - etiology Respiratory Distress Syndrome - therapy SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Science & Technology Severe acute respiratory syndrome coronavirus 2 Thrombosis Tomography, X-Ray Computed Ventilators |
| title | Severe Covid-19 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T12%3A38%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Severe%20Covid-19&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Berlin,%20David%20A&rft.date=2020-12-17&rft.volume=383&rft.issue=25&rft.spage=2451&rft.epage=2460&rft.pages=2451-2460&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMcp2009575&rft_dat=%3Cproquest_cross%3E2470668590%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2470668590&rft_id=info:pmid/32412710&rfr_iscdi=true |