Intrathecal Methylprednisolone for Postherpetic Neuralgia
To the Editor: Kotani and colleagues (Nov. 23 issue) 1 recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic resonance imaging in patients with acute herpes...
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| Veröffentlicht in: | The New England journal of medicine 2001-03, Vol.344 (13), p.1019-1022 |
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| container_title | The New England journal of medicine |
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| creator | Lampe, J B Hindinger, C Reichmann, H |
| description | To the Editor:
Kotani and colleagues (Nov. 23 issue)
1
recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic resonance imaging in patients with acute herpes zoster are not persistent. The neuropathological reference that Kotani et al. cite
2
does not demonstrate polymorphonuclear leukocytes or “marked inflammation around the spinal cord, with massive infiltration and accumulation of lymphocytes.” The usual association between neutrophil inflammation and interleukin-8 calls into question reliance on the level of interleukin-8 in acellular cerebrospinal fluid.
3
The authors' hypothesis that “postherpetic neuralgia provokes an . . . |
| doi_str_mv | 10.1056/NEJM200103293441314 |
| format | Article |
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Kotani and colleagues (Nov. 23 issue)
1
recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic resonance imaging in patients with acute herpes zoster are not persistent. The neuropathological reference that Kotani et al. cite
2
does not demonstrate polymorphonuclear leukocytes or “marked inflammation around the spinal cord, with massive infiltration and accumulation of lymphocytes.” The usual association between neutrophil inflammation and interleukin-8 calls into question reliance on the level of interleukin-8 in acellular cerebrospinal fluid.
3
The authors' hypothesis that “postherpetic neuralgia provokes an . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200103293441314</identifier><identifier>PMID: 11280319</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - adverse effects ; Herpes Zoster - complications ; Herpesvirus 3, Human - drug effects ; Humans ; Injections, Spinal ; Methylprednisolone - administration & dosage ; Methylprednisolone - adverse effects ; Neuralgia - drug therapy ; Neuralgia - etiology ; Virus Replication - drug effects</subject><ispartof>The New England journal of medicine, 2001-03, Vol.344 (13), p.1019-1022</ispartof><rights>Copyright © 2001 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-1149f2eef99260233f37f92bdea2d7d0c964e2177a63176deadfcfa83916c5853</citedby><cites>FETCH-LOGICAL-c461t-1149f2eef99260233f37f92bdea2d7d0c964e2177a63176deadfcfa83916c5853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200103293441314$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200103293441314$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11280319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lampe, J B</creatorcontrib><creatorcontrib>Hindinger, C</creatorcontrib><creatorcontrib>Reichmann, H</creatorcontrib><title>Intrathecal Methylprednisolone for Postherpetic Neuralgia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Kotani and colleagues (Nov. 23 issue)
1
recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic resonance imaging in patients with acute herpes zoster are not persistent. The neuropathological reference that Kotani et al. cite
2
does not demonstrate polymorphonuclear leukocytes or “marked inflammation around the spinal cord, with massive infiltration and accumulation of lymphocytes.” The usual association between neutrophil inflammation and interleukin-8 calls into question reliance on the level of interleukin-8 in acellular cerebrospinal fluid.
3
The authors' hypothesis that “postherpetic neuralgia provokes an . . .</description><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>Herpes Zoster - complications</subject><subject>Herpesvirus 3, Human - drug effects</subject><subject>Humans</subject><subject>Injections, Spinal</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - adverse effects</subject><subject>Neuralgia - drug therapy</subject><subject>Neuralgia - etiology</subject><subject>Virus Replication - drug effects</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotlY_gSB7l9VMJpvdHKW0WmmrBz0vaXZit-w_ku2h396VFryIcxkYfu8N7zF2C_wBeKIe17PXleAcOAqNUgKCPGNjSBBjKbk6Z2PORRbLVOOIXYWw48OA1JdsBCAyjqDHTC-a3pt-S9ZU0Yr67aHqPBVNGdqqbShyrY_e2zAAvqO-tNGa9t5UX6W5ZhfOVIFuTnvCPuezj-lLvHx7XkyflrGVCvoYho9OEDmtheIC0WHqtNgUZESRFtxqJUlAmhqFkKrhXDjrTIYalE2yBCcMj77WtyF4cnnny9r4Qw48_yki_6OIQXV3VHX7TU3Fr-aUfADuj0Bdh7yhXf2v3TeqyGTx</recordid><startdate>20010329</startdate><enddate>20010329</enddate><creator>Lampe, J B</creator><creator>Hindinger, C</creator><creator>Reichmann, H</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010329</creationdate><title>Intrathecal Methylprednisolone for Postherpetic Neuralgia</title><author>Lampe, J B ; Hindinger, C ; Reichmann, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-1149f2eef99260233f37f92bdea2d7d0c964e2177a63176deadfcfa83916c5853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - adverse effects</topic><topic>Herpes Zoster - complications</topic><topic>Herpesvirus 3, Human - drug effects</topic><topic>Humans</topic><topic>Injections, Spinal</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - adverse effects</topic><topic>Neuralgia - drug therapy</topic><topic>Neuralgia - etiology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lampe, J B</creatorcontrib><creatorcontrib>Hindinger, C</creatorcontrib><creatorcontrib>Reichmann, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lampe, J B</au><au>Hindinger, C</au><au>Reichmann, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal Methylprednisolone for Postherpetic Neuralgia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2001-03-29</date><risdate>2001</risdate><volume>344</volume><issue>13</issue><spage>1019</spage><epage>1022</epage><pages>1019-1022</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Kotani and colleagues (Nov. 23 issue)
1
recommend intrathecal methylprednisolone acetate for treatment of intractable postherpetic neuralgia due to persistent inflammation. But the abnormalities in the cerebrospinal fluid and on magnetic resonance imaging in patients with acute herpes zoster are not persistent. The neuropathological reference that Kotani et al. cite
2
does not demonstrate polymorphonuclear leukocytes or “marked inflammation around the spinal cord, with massive infiltration and accumulation of lymphocytes.” The usual association between neutrophil inflammation and interleukin-8 calls into question reliance on the level of interleukin-8 in acellular cerebrospinal fluid.
3
The authors' hypothesis that “postherpetic neuralgia provokes an . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>11280319</pmid><doi>10.1056/NEJM200103293441314</doi><tpages>4</tpages></addata></record> |
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| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Herpes Zoster - complications Herpesvirus 3, Human - drug effects Humans Injections, Spinal Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Neuralgia - drug therapy Neuralgia - etiology Virus Replication - drug effects |
| title | Intrathecal Methylprednisolone for Postherpetic Neuralgia |
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