Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane
To the Editor: Astier and Paraire (Sept. 25 issue) 1 describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that “laboratory studies are u...
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| Veröffentlicht in: | The New England journal of medicine 1998-01, Vol.338 (3), p.201-202 |
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| container_title | The New England journal of medicine |
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| creator | Johansson, J S |
| description | To the Editor:
Astier and Paraire (Sept. 25 issue)
1
describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that “laboratory studies are urgently needed to determine the toxicity profile of 1,1-dichloro-1-fluoroethane and propose guidelines for its safe handling.”
Investigations of the physiologic effects of 1,1-dichloro-1-fluoroethane were performed in the 1940s and 1950s when this and related compounds were being tested for their usefulness as inhalational anesthetics. In 1946 Robbins
2
reported that 1,1-dichloro-1-fluoroethane was an anesthetic in mice and . . . |
| doi_str_mv | 10.1056/NEJM199801153380318 |
| format | Article |
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Astier and Paraire (Sept. 25 issue)
1
describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that “laboratory studies are urgently needed to determine the toxicity profile of 1,1-dichloro-1-fluoroethane and propose guidelines for its safe handling.”
Investigations of the physiologic effects of 1,1-dichloro-1-fluoroethane were performed in the 1940s and 1950s when this and related compounds were being tested for their usefulness as inhalational anesthetics. In 1946 Robbins
2
reported that 1,1-dichloro-1-fluoroethane was an anesthetic in mice and . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199801153380318</identifier><identifier>PMID: 9441232</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Animals ; Chlorofluorocarbons - poisoning ; Chlorofluorocarbons, Ethane ; Heart - drug effects ; Humans ; Male ; Solvents - poisoning</subject><ispartof>The New England journal of medicine, 1998-01, Vol.338 (3), p.201-202</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-27d59acb738ff826617ad98238733c10027f12879d694f6ede6f29bd35dc70163</citedby><cites>FETCH-LOGICAL-c373t-27d59acb738ff826617ad98238733c10027f12879d694f6ede6f29bd35dc70163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199801153380318$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199801153380318$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9441232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johansson, J S</creatorcontrib><title>Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Astier and Paraire (Sept. 25 issue)
1
describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that “laboratory studies are urgently needed to determine the toxicity profile of 1,1-dichloro-1-fluoroethane and propose guidelines for its safe handling.”
Investigations of the physiologic effects of 1,1-dichloro-1-fluoroethane were performed in the 1940s and 1950s when this and related compounds were being tested for their usefulness as inhalational anesthetics. In 1946 Robbins
2
reported that 1,1-dichloro-1-fluoroethane was an anesthetic in mice and . . .</description><subject>Animals</subject><subject>Chlorofluorocarbons - poisoning</subject><subject>Chlorofluorocarbons, Ethane</subject><subject>Heart - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Solvents - poisoning</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKA0EQHESJMfoFIuSuo9PTs_M4SpLVSNSLnpfJPMiGfYTdDerfuzHBk9iXLiiqqCpCLoHdAkvk3cvs6RmM0QwgQdQMQR-R4Q5TIZg8JkPGuKZCGTwlZ227Zv2BMAMyMEIARz4kmNrOFuN51dWfubNdXlfjj7xbjeEG6DR3q6Juago0LbY9CN3KVuGcnERbtOHi8EfkPZ29TR7p4vVhPrlfUIcKO8qVT4x1S4U6Rs2lBGW90Ry1QnTQZ1MRuFbGSyOiDD7IyM3SY-KdYiBx1Kf78XVN3bZNiNmmyUvbfGXAst0C2R8L9KqrvWqzXZbB_2oOlXv-es-XZZtVYV3-6_YNGERgMw</recordid><startdate>19980115</startdate><enddate>19980115</enddate><creator>Johansson, J S</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980115</creationdate><title>Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane</title><author>Johansson, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-27d59acb738ff826617ad98238733c10027f12879d694f6ede6f29bd35dc70163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Chlorofluorocarbons - poisoning</topic><topic>Chlorofluorocarbons, Ethane</topic><topic>Heart - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Solvents - poisoning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johansson, J S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johansson, J S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1998-01-15</date><risdate>1998</risdate><volume>338</volume><issue>3</issue><spage>201</spage><epage>202</epage><pages>201-202</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Astier and Paraire (Sept. 25 issue)
1
describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that “laboratory studies are urgently needed to determine the toxicity profile of 1,1-dichloro-1-fluoroethane and propose guidelines for its safe handling.”
Investigations of the physiologic effects of 1,1-dichloro-1-fluoroethane were performed in the 1940s and 1950s when this and related compounds were being tested for their usefulness as inhalational anesthetics. In 1946 Robbins
2
reported that 1,1-dichloro-1-fluoroethane was an anesthetic in mice and . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>9441232</pmid><doi>10.1056/NEJM199801153380318</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-01, Vol.338 (3), p.201-202 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_crossref_primary_10_1056_NEJM199801153380318 |
| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Animals Chlorofluorocarbons - poisoning Chlorofluorocarbons, Ethane Heart - drug effects Humans Male Solvents - poisoning |
| title | Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane |
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