Aluminum Toxicity in Preterm Infants
To the Editor: The observation by Bishop et al. (May 29 issue) 1 regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis. First, toxicity may be a function of serum aluminum concentrations, bu...
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| Veröffentlicht in: | The New England journal of medicine 1997-10, Vol.337 (15), p.1090-1091 |
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| container_title | The New England journal of medicine |
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| creator | Driscoll, W R Cummings, J J Zorn, W |
| description | To the Editor:
The observation by Bishop et al. (May 29 issue)
1
regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.
First, toxicity may be a function of serum aluminum concentrations, but these were not measured. The underlying assumption that increased intake leads to increased serum concentrations may not be valid; Koo et al. found no difference in serum aluminum concentrations in preterm neonates with various levels of aluminum intake.
2
Increased intake could be offset by an increase in urinary excretion; without measuring the latter, this . . . |
| doi_str_mv | 10.1056/NEJM199710093371517 |
| format | Article |
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The observation by Bishop et al. (May 29 issue)
1
regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.
First, toxicity may be a function of serum aluminum concentrations, but these were not measured. The underlying assumption that increased intake leads to increased serum concentrations may not be valid; Koo et al. found no difference in serum aluminum concentrations in preterm neonates with various levels of aluminum intake.
2
Increased intake could be offset by an increase in urinary excretion; without measuring the latter, this . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199710093371517</identifier><identifier>PMID: 9324646</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aluminum - adverse effects ; Aluminum - blood ; Child Development - drug effects ; Humans ; Infant Food - adverse effects ; Infant, Newborn ; Infant, Premature - blood ; Intelligence - drug effects ; Parenteral Nutrition</subject><ispartof>The New England journal of medicine, 1997-10, Vol.337 (15), p.1090-1091</ispartof><rights>Copyright © 1997 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-59ed125bfbf1f1d9baee331bd8f47456bcdd46d7025ffa1f24fee02e9152998a3</citedby><cites>FETCH-LOGICAL-c375t-59ed125bfbf1f1d9baee331bd8f47456bcdd46d7025ffa1f24fee02e9152998a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199710093371517$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199710093371517$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9324646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Driscoll, W R</creatorcontrib><creatorcontrib>Cummings, J J</creatorcontrib><creatorcontrib>Zorn, W</creatorcontrib><title>Aluminum Toxicity in Preterm Infants</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The observation by Bishop et al. (May 29 issue)
1
regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.
First, toxicity may be a function of serum aluminum concentrations, but these were not measured. The underlying assumption that increased intake leads to increased serum concentrations may not be valid; Koo et al. found no difference in serum aluminum concentrations in preterm neonates with various levels of aluminum intake.
2
Increased intake could be offset by an increase in urinary excretion; without measuring the latter, this . . .</description><subject>Aluminum - adverse effects</subject><subject>Aluminum - blood</subject><subject>Child Development - drug effects</subject><subject>Humans</subject><subject>Infant Food - adverse effects</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Intelligence - drug effects</subject><subject>Parenteral Nutrition</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j81LwzAchoMos07_AhF68CbV_PLZHMeYOpkfh3kuSZNAx9KNpAX331vp8CS-l_fw8rzwIHQN-B4wFw9vi5dXUEoCxopSCRzkCcqAU1owhsUpyjAmZcGkoufoIqUNHgJMTdBEUcIEExm6nW370LR9yNe7r6ZuukPetPlHdJ2LIV-2XrddukRnXm-Tuzr2FH0-Ltbz52L1_rScz1ZFTSXvCq6cBcKNNx48WGW0c5SCsaVnknFhamuZsBIT7r0GT5h3DhOngBOlSk2niI6_ddylFJ2v9rEJOh4qwNWPcvWH8kDdjNS-N8HZX-boOOx34x5Cqlq3Cf--fQMsUl0i</recordid><startdate>19971009</startdate><enddate>19971009</enddate><creator>Driscoll, W R</creator><creator>Cummings, J J</creator><creator>Zorn, W</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19971009</creationdate><title>Aluminum Toxicity in Preterm Infants</title><author>Driscoll, W R ; Cummings, J J ; Zorn, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-59ed125bfbf1f1d9baee331bd8f47456bcdd46d7025ffa1f24fee02e9152998a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aluminum - adverse effects</topic><topic>Aluminum - blood</topic><topic>Child Development - drug effects</topic><topic>Humans</topic><topic>Infant Food - adverse effects</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Intelligence - drug effects</topic><topic>Parenteral Nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Driscoll, W R</creatorcontrib><creatorcontrib>Cummings, J J</creatorcontrib><creatorcontrib>Zorn, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Driscoll, W R</au><au>Cummings, J J</au><au>Zorn, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aluminum Toxicity in Preterm Infants</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1997-10-09</date><risdate>1997</risdate><volume>337</volume><issue>15</issue><spage>1090</spage><epage>1091</epage><pages>1090-1091</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
The observation by Bishop et al. (May 29 issue)
1
regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.
First, toxicity may be a function of serum aluminum concentrations, but these were not measured. The underlying assumption that increased intake leads to increased serum concentrations may not be valid; Koo et al. found no difference in serum aluminum concentrations in preterm neonates with various levels of aluminum intake.
2
Increased intake could be offset by an increase in urinary excretion; without measuring the latter, this . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>9324646</pmid><doi>10.1056/NEJM199710093371517</doi><tpages>2</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 1997-10, Vol.337 (15), p.1090-1091 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aluminum - adverse effects Aluminum - blood Child Development - drug effects Humans Infant Food - adverse effects Infant, Newborn Infant, Premature - blood Intelligence - drug effects Parenteral Nutrition |
| title | Aluminum Toxicity in Preterm Infants |
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