Flupentixol-Induced Aversion to Crack Cocaine
To the Editor: Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular...
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| Veröffentlicht in: | The New England journal of medicine 1996-05, Vol.334 (20), p.1340-1341 |
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| container_title | The New England journal of medicine |
| container_volume | 334 |
| creator | Khalsa-Denison, M. Elena Gawin, Frank H Jatlow, Peter |
| description | To the Editor:
Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,
1
a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action . . . |
| doi_str_mv | 10.1056/NEJM199605163342018 |
| format | Article |
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Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,
1
a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199605163342018</identifier><identifier>PMID: 8609966</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Akathisia, Drug-Induced - etiology ; Crack Cocaine ; Flupenthixol - therapeutic use ; Humans ; Male ; Middle Aged ; Substance-Related Disorders - drug therapy</subject><ispartof>The New England journal of medicine, 1996-05, Vol.334 (20), p.1340-1341</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-faef8b22e74446b9476406f19cfd75d639a8e104909b17d049403ecf285c38c53</citedby><cites>FETCH-LOGICAL-c422t-faef8b22e74446b9476406f19cfd75d639a8e104909b17d049403ecf285c38c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199605163342018$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199605163342018$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8609966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalsa-Denison, M. Elena</creatorcontrib><creatorcontrib>Gawin, Frank H</creatorcontrib><creatorcontrib>Jatlow, Peter</creatorcontrib><title>Flupentixol-Induced Aversion to Crack Cocaine</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,
1
a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action . . .</description><subject>Adult</subject><subject>Akathisia, Drug-Induced - etiology</subject><subject>Crack Cocaine</subject><subject>Flupenthixol - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Substance-Related Disorders - drug therapy</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j01LxDAQhoMoa139BSL0LtHJZ5PjUnZ1ZdWLnkubJtC1XzSt6L_fSBdP4lxm4OV5mQehawJ3BIS8f1k_PROtJQgiGeMUiDpBERGMYc5BnqIIgCrME83O0YX3ewhDuF6ghZIQQBkhvKmn3rZj9dXVeNuWk7FlvPq0g6-6Nh67OB1y8xGnncmr1l6iM5fX3l4d9xK9b9Zv6SPevT5s09UOG07piF1unSootQnnXBaaJzL844g2rkxEKZnOlSXANeiCJGU4ODBrHFXCMGUEWyI295qh836wLuuHqsmH74xA9uOe_eEeqJuZ6qeiseUvc5QN-e2cN43PWrtv_m07ACblXs8</recordid><startdate>19960516</startdate><enddate>19960516</enddate><creator>Khalsa-Denison, M. Elena</creator><creator>Gawin, Frank H</creator><creator>Jatlow, Peter</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19960516</creationdate><title>Flupentixol-Induced Aversion to Crack Cocaine</title><author>Khalsa-Denison, M. Elena ; Gawin, Frank H ; Jatlow, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-faef8b22e74446b9476406f19cfd75d639a8e104909b17d049403ecf285c38c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Akathisia, Drug-Induced - etiology</topic><topic>Crack Cocaine</topic><topic>Flupenthixol - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Substance-Related Disorders - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalsa-Denison, M. Elena</creatorcontrib><creatorcontrib>Gawin, Frank H</creatorcontrib><creatorcontrib>Jatlow, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalsa-Denison, M. Elena</au><au>Gawin, Frank H</au><au>Jatlow, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flupentixol-Induced Aversion to Crack Cocaine</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1996-05-16</date><risdate>1996</risdate><volume>334</volume><issue>20</issue><spage>1340</spage><epage>1341</epage><pages>1340-1341</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,
1
a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>8609966</pmid><doi>10.1056/NEJM199605163342018</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-05, Vol.334 (20), p.1340-1341 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_crossref_primary_10_1056_NEJM199605163342018 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Akathisia, Drug-Induced - etiology Crack Cocaine Flupenthixol - therapeutic use Humans Male Middle Aged Substance-Related Disorders - drug therapy |
| title | Flupentixol-Induced Aversion to Crack Cocaine |
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