Treatment of Life-Threatening Infantile Hemangiomas with Vincristine
To the Editor: We describe two cases of corticosteroid-resistant, life-endangering hemangioma treated with vincristine: a benign hemangioendothelioma in a patient with Kasabach-Merritt syndrome and a liver hemangioendothelioma. Mortality rates among patients with these kinds of hemangioma can be as...
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| Veröffentlicht in: | The New England journal of medicine 1995-07, Vol.333 (1), p.69-69 |
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| container_title | The New England journal of medicine |
| container_volume | 333 |
| creator | Payarols, Jaime Perez Masferrer, Jose Pardo Bellvert, Cristina Gomez |
| description | To the Editor:
We describe two cases of corticosteroid-resistant, life-endangering hemangioma treated with vincristine: a benign hemangioendothelioma in a patient with Kasabach-Merritt syndrome and a liver hemangioendothelioma. Mortality rates among patients with these kinds of hemangioma can be as high as 40 percent and may be more than 50 percent if poor prognostic factors are present.
1
,
2
Corticosteroids are the medical treatment of choice, except for resistant cases,
3
which are not infrequent.
The first patient was a nine-month-old baby who presented with a tumor 10 cm in diameter in the left supraclavicular region and a platelet count of 7400 per . . . |
| doi_str_mv | 10.1056/NEJM199507063330120 |
| format | Article |
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We describe two cases of corticosteroid-resistant, life-endangering hemangioma treated with vincristine: a benign hemangioendothelioma in a patient with Kasabach-Merritt syndrome and a liver hemangioendothelioma. Mortality rates among patients with these kinds of hemangioma can be as high as 40 percent and may be more than 50 percent if poor prognostic factors are present.
1
,
2
Corticosteroids are the medical treatment of choice, except for resistant cases,
3
which are not infrequent.
The first patient was a nine-month-old baby who presented with a tumor 10 cm in diameter in the left supraclavicular region and a platelet count of 7400 per . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199507063330120</identifier><identifier>PMID: 7777010</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Drug Resistance ; Hemangioendothelioma - drug therapy ; Humans ; Infant ; Infant, Newborn ; Liver Neoplasms - drug therapy ; Soft Tissue Neoplasms - drug therapy ; Syndrome ; Thrombocytopenia ; Vincristine - therapeutic use</subject><ispartof>The New England journal of medicine, 1995-07, Vol.333 (1), p.69-69</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f7c25eafbf740d0676ce5e98b83a82b098db8c4428ef39497c226b353279eb7a3</citedby><cites>FETCH-LOGICAL-c386t-f7c25eafbf740d0676ce5e98b83a82b098db8c4428ef39497c226b353279eb7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199507063330120$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199507063330120$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7777010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Payarols, Jaime Perez</creatorcontrib><creatorcontrib>Masferrer, Jose Pardo</creatorcontrib><creatorcontrib>Bellvert, Cristina Gomez</creatorcontrib><title>Treatment of Life-Threatening Infantile Hemangiomas with Vincristine</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
We describe two cases of corticosteroid-resistant, life-endangering hemangioma treated with vincristine: a benign hemangioendothelioma in a patient with Kasabach-Merritt syndrome and a liver hemangioendothelioma. Mortality rates among patients with these kinds of hemangioma can be as high as 40 percent and may be more than 50 percent if poor prognostic factors are present.
1
,
2
Corticosteroids are the medical treatment of choice, except for resistant cases,
3
which are not infrequent.
The first patient was a nine-month-old baby who presented with a tumor 10 cm in diameter in the left supraclavicular region and a platelet count of 7400 per . . .</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Drug Resistance</subject><subject>Hemangioendothelioma - drug therapy</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Soft Tissue Neoplasms - drug therapy</subject><subject>Syndrome</subject><subject>Thrombocytopenia</subject><subject>Vincristine - therapeutic use</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAjEUhhujQUSfwJjM3oyeXmbaLg2iYFA36HbSDqdQQguZjiG-vUMgroz_5iTnvyw-Qq4p3FEoyvu30csr1boACSXnHCiDE9KnBee5EFCekj4AU7mQmp-Ti5RW0IkK3SM92Qko9MnjrEHTBoxttnHZ1DvMZ8v9C6OPi2wSnYmtX2M2xmDiwm-CSdnOt8vs08e68an1ES_JmTPrhFfHOyAfT6PZcJxP358nw4dpXnNVtrmTNSvQOOukgDmUsqyxQK2s4kYxC1rNraqFYAod10J3cVZaXnAmNVpp-IDww27dbFJq0FXbxgfTfFcUqj2S6g8kXevm0Np-2YDz386RQeffHvwQUhVxFf5d-wH2nGhG</recordid><startdate>19950706</startdate><enddate>19950706</enddate><creator>Payarols, Jaime Perez</creator><creator>Masferrer, Jose Pardo</creator><creator>Bellvert, Cristina Gomez</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950706</creationdate><title>Treatment of Life-Threatening Infantile Hemangiomas with Vincristine</title><author>Payarols, Jaime Perez ; Masferrer, Jose Pardo ; Bellvert, Cristina Gomez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f7c25eafbf740d0676ce5e98b83a82b098db8c4428ef39497c226b353279eb7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Drug Resistance</topic><topic>Hemangioendothelioma - drug therapy</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Soft Tissue Neoplasms - drug therapy</topic><topic>Syndrome</topic><topic>Thrombocytopenia</topic><topic>Vincristine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Payarols, Jaime Perez</creatorcontrib><creatorcontrib>Masferrer, Jose Pardo</creatorcontrib><creatorcontrib>Bellvert, Cristina Gomez</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Payarols, Jaime Perez</au><au>Masferrer, Jose Pardo</au><au>Bellvert, Cristina Gomez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Life-Threatening Infantile Hemangiomas with Vincristine</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1995-07-06</date><risdate>1995</risdate><volume>333</volume><issue>1</issue><spage>69</spage><epage>69</epage><pages>69-69</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
We describe two cases of corticosteroid-resistant, life-endangering hemangioma treated with vincristine: a benign hemangioendothelioma in a patient with Kasabach-Merritt syndrome and a liver hemangioendothelioma. Mortality rates among patients with these kinds of hemangioma can be as high as 40 percent and may be more than 50 percent if poor prognostic factors are present.
1
,
2
Corticosteroids are the medical treatment of choice, except for resistant cases,
3
which are not infrequent.
The first patient was a nine-month-old baby who presented with a tumor 10 cm in diameter in the left supraclavicular region and a platelet count of 7400 per . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>7777010</pmid><doi>10.1056/NEJM199507063330120</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1995-07, Vol.333 (1), p.69-69 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_crossref_primary_10_1056_NEJM199507063330120 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adrenal Cortex Hormones - therapeutic use Drug Resistance Hemangioendothelioma - drug therapy Humans Infant Infant, Newborn Liver Neoplasms - drug therapy Soft Tissue Neoplasms - drug therapy Syndrome Thrombocytopenia Vincristine - therapeutic use |
| title | Treatment of Life-Threatening Infantile Hemangiomas with Vincristine |
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