Nifedipine in Severe Aortic Regurgitation

Nifedipine in Severe Aortic Regurgitation

To the Editor: It is unfortunate that Scognamiglio et al. (Sept. 15 issue) 1 chose to use digoxin instead of placebo to study the effects of nifedipine in asymptomatic patients with chronic, severe aortic regurgitation. Almost two decades since the short-term beneficial effects of vasodilator therap...

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Veröffentlicht in:The New England journal of medicine 1995-05, Vol.332 (19), p.1302-1304
Hauptverfasser: Manyari, D E, Yunus, A
Format: Artikel
Sprache:eng
Schlagworte:
Aortic Valve Insufficiency - drug therapy
Digoxin - adverse effects
Humans
Nifedipine - therapeutic use
Ventricular Function, Left - drug effects
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container_issue 19
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container_title The New England journal of medicine
container_volume 332
creator Manyari, D E
Yunus, A
description To the Editor: It is unfortunate that Scognamiglio et al. (Sept. 15 issue) 1 chose to use digoxin instead of placebo to study the effects of nifedipine in asymptomatic patients with chronic, severe aortic regurgitation. Almost two decades since the short-term beneficial effects of vasodilator therapy in severe aortic regurgitation were first reported, 2 clinicians still await proof that vasodilator therapy reduces or delays the need for aortic-valve replacement in asymptomatic patients with severe, chronic aortic regurgitation. Although some authors 3 , 4 have promoted the routine use of vasodilators to delay the need for valve replacement in these patients, an informal survey we . . .
doi_str_mv 10.1056/NEJM199505113321913
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine
subjects Aortic Valve Insufficiency - drug therapy
Digoxin - adverse effects
Humans
Nifedipine - therapeutic use
Ventricular Function, Left - drug effects
title Nifedipine in Severe Aortic Regurgitation
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