Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection
Although disease develops within 10 years in most persons infected with human immunodeficiency virus type 1 (HIV-1), some remain symptom-free for prolonged periods. 1 , 2 Most long-term asymptomatic survivors of HIV-1 infection still have evidence of disease progression in the form of declining CD4+...
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| Veröffentlicht in: | The New England journal of medicine 1995-01, Vol.332 (4), p.228-232 |
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| container_title | The New England journal of medicine |
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| creator | Kirchhoff, Frank Greenough, Thomas C Brettler, Doreen B Sullivan, John L Desrosiers, Ronald C |
| description | Although disease develops within 10 years in most persons infected with human immunodeficiency virus type 1 (HIV-1), some remain symptom-free for prolonged periods.
1
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2
Most long-term asymptomatic survivors of HIV-1 infection still have evidence of disease progression in the form of declining CD4+ lymphocyte concentrations. However, some rare persons not only are asymptomatic but also maintain stable levels of CD4+ lymphocytes in the normal or near-normal range. Although the definition of nonprogression may vary, approximately 5 percent of seropositive persons have shown no HIV-related disease or declines in CD4+ cell counts despite 10 or more years of documented HIV-1 infection. . . . |
| doi_str_mv | 10.1056/NEJM199501263320405 |
| format | Article |
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Most long-term asymptomatic survivors of HIV-1 infection still have evidence of disease progression in the form of declining CD4+ lymphocyte concentrations. However, some rare persons not only are asymptomatic but also maintain stable levels of CD4+ lymphocytes in the normal or near-normal range. Although the definition of nonprogression may vary, approximately 5 percent of seropositive persons have shown no HIV-related disease or declines in CD4+ cell counts despite 10 or more years of documented HIV-1 infection. . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199501263320405</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Biological and medical sciences ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Medical sciences</subject><ispartof>The New England journal of medicine, 1995-01, Vol.332 (4), p.228-232</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3595-2b130e48feafce046108e32cb43fb7f61a6d4930382893df9ad8f9a4a77bc6683</citedby><cites>FETCH-LOGICAL-c3595-2b130e48feafce046108e32cb43fb7f61a6d4930382893df9ad8f9a4a77bc6683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199501263320405$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199501263320405$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2745,2746,26082,27903,27904,52361,54043</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3392193$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirchhoff, Frank</creatorcontrib><creatorcontrib>Greenough, Thomas C</creatorcontrib><creatorcontrib>Brettler, Doreen B</creatorcontrib><creatorcontrib>Sullivan, John L</creatorcontrib><creatorcontrib>Desrosiers, Ronald C</creatorcontrib><title>Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection</title><title>The New England journal of medicine</title><description>Although disease develops within 10 years in most persons infected with human immunodeficiency virus type 1 (HIV-1), some remain symptom-free for prolonged periods.
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Most long-term asymptomatic survivors of HIV-1 infection still have evidence of disease progression in the form of declining CD4+ lymphocyte concentrations. However, some rare persons not only are asymptomatic but also maintain stable levels of CD4+ lymphocytes in the normal or near-normal range. Although the definition of nonprogression may vary, approximately 5 percent of seropositive persons have shown no HIV-related disease or declines in CD4+ cell counts despite 10 or more years of documented HIV-1 infection. . . .</description><subject>Biological and medical sciences</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAQhi0EEqXwBCwe2FDA9jlOPFZVoUUFhhYWhshxzyVV4xQ7LeLtSVXEhLjhTjr93zf8hFxydsNZqm6fRg-PXOuUcaEABJMsPSI9ngIkUjJ1THqMiTyRmYZTchbjinXDpe6Rt0EZ0VukjaMT3xrbUo-OzvBju39HWnlq6LTxy2SOoaazbdhVuybQz6p9p0-N34RmGTDGaod0PHlNeKdxaNuq8efkxJl1xIuf2ycvd6P5cJxMn-8nw8E0sZDqNBElB4Yyd2icRSYVZzmCsKUEV2ZOcaMWUgODXOQaFk6bRd4tabKstErl0Cdw8NrQxBjQFZtQ1SZ8FZwV-36KP_rpqKsDtTHRmrULxtsq_qIAWnANXez6EKvrWHhc1f9KvwEAoHC6</recordid><startdate>19950126</startdate><enddate>19950126</enddate><creator>Kirchhoff, Frank</creator><creator>Greenough, Thomas C</creator><creator>Brettler, Doreen B</creator><creator>Sullivan, John L</creator><creator>Desrosiers, Ronald C</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950126</creationdate><title>Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection</title><author>Kirchhoff, Frank ; Greenough, Thomas C ; Brettler, Doreen B ; Sullivan, John L ; Desrosiers, Ronald C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3595-2b130e48feafce046108e32cb43fb7f61a6d4930382893df9ad8f9a4a77bc6683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirchhoff, Frank</creatorcontrib><creatorcontrib>Greenough, Thomas C</creatorcontrib><creatorcontrib>Brettler, Doreen B</creatorcontrib><creatorcontrib>Sullivan, John L</creatorcontrib><creatorcontrib>Desrosiers, Ronald C</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirchhoff, Frank</au><au>Greenough, Thomas C</au><au>Brettler, Doreen B</au><au>Sullivan, John L</au><au>Desrosiers, Ronald C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection</atitle><jtitle>The New England journal of medicine</jtitle><date>1995-01-26</date><risdate>1995</risdate><volume>332</volume><issue>4</issue><spage>228</spage><epage>232</epage><pages>228-232</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Although disease develops within 10 years in most persons infected with human immunodeficiency virus type 1 (HIV-1), some remain symptom-free for prolonged periods.
1
,
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Most long-term asymptomatic survivors of HIV-1 infection still have evidence of disease progression in the form of declining CD4+ lymphocyte concentrations. However, some rare persons not only are asymptomatic but also maintain stable levels of CD4+ lymphocytes in the normal or near-normal range. Although the definition of nonprogression may vary, approximately 5 percent of seropositive persons have shown no HIV-related disease or declines in CD4+ cell counts despite 10 or more years of documented HIV-1 infection. . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><doi>10.1056/NEJM199501263320405</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1995-01, Vol.332 (4), p.228-232 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | New England Journal of Medicine Current; ProQuest Central UK/Ireland; EZB Electronic Journals Library |
| subjects | Biological and medical sciences Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Medical sciences |
| title | Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection |
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