Treatment of Lymphangioleiomyomatosis
To the Editor: The article on lymphangioleiomyomatosis (LAM) by Taylor et al. (Nov. 1 issue)* was a very useful addition to the limited literature on the disease. I take issue with one of their recommendations, however. Despite their own finding that oophorectomy is not associated with an observable...
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| Veröffentlicht in: | The New England journal of medicine 1991-07, Vol.325 (1), p.63-64 |
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| container_title | The New England journal of medicine |
| container_volume | 325 |
| creator | Goodenberger, Daniel M Dhand, Sandeep Eliasson, Arn H Phillips, Yancy Y Tenholder, Michael F Goodwin, Thomas Murphy Zahner, Johannes Borst, Mathias M Worth, Heinrich Raffin, Thomas A Taylor, James R Ryu, Jay Colby, Thomas V |
| description | To the Editor:
The article on lymphangioleiomyomatosis (LAM) by Taylor et al. (Nov. 1 issue)* was a very useful addition to the limited literature on the disease. I take issue with one of their recommendations, however. Despite their own finding that oophorectomy is not associated with an observable clinical benefit, they continue to recommend it as second-line therapy because studies to date cannot exclude a possible benefit. Perhaps the following hypothetical encounter with a patient will illustrate my point.
"Mr. Jones, your open-lung biopsy showed a form of interstitial lung disease about which we know very little. The natural history . . . |
| doi_str_mv | 10.1056/NEJM199107043250115 |
| format | Article |
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The article on lymphangioleiomyomatosis (LAM) by Taylor et al. (Nov. 1 issue)* was a very useful addition to the limited literature on the disease. I take issue with one of their recommendations, however. Despite their own finding that oophorectomy is not associated with an observable clinical benefit, they continue to recommend it as second-line therapy because studies to date cannot exclude a possible benefit. Perhaps the following hypothetical encounter with a patient will illustrate my point.
"Mr. Jones, your open-lung biopsy showed a form of interstitial lung disease about which we know very little. The natural history . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199107043250115</identifier><identifier>PMID: 2046715</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adolescent ; Combined Modality Therapy ; Female ; Humans ; Lymphangiomyoma - therapy ; Male</subject><ispartof>The New England journal of medicine, 1991-07, Vol.325 (1), p.63-64</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c287t-976211ea01025aaf83481e5ce9c4d495ec717fe5fdb8e772bfad0458308f5d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199107043250115$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199107043250115$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2046715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goodenberger, Daniel M</creatorcontrib><creatorcontrib>Dhand, Sandeep</creatorcontrib><creatorcontrib>Eliasson, Arn H</creatorcontrib><creatorcontrib>Phillips, Yancy Y</creatorcontrib><creatorcontrib>Tenholder, Michael F</creatorcontrib><creatorcontrib>Goodwin, Thomas Murphy</creatorcontrib><creatorcontrib>Zahner, Johannes</creatorcontrib><creatorcontrib>Borst, Mathias M</creatorcontrib><creatorcontrib>Worth, Heinrich</creatorcontrib><creatorcontrib>Raffin, Thomas A</creatorcontrib><creatorcontrib>Taylor, James R</creatorcontrib><creatorcontrib>Ryu, Jay</creatorcontrib><creatorcontrib>Colby, Thomas V</creatorcontrib><title>Treatment of Lymphangioleiomyomatosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The article on lymphangioleiomyomatosis (LAM) by Taylor et al. (Nov. 1 issue)* was a very useful addition to the limited literature on the disease. I take issue with one of their recommendations, however. Despite their own finding that oophorectomy is not associated with an observable clinical benefit, they continue to recommend it as second-line therapy because studies to date cannot exclude a possible benefit. Perhaps the following hypothetical encounter with a patient will illustrate my point.
"Mr. Jones, your open-lung biopsy showed a form of interstitial lung disease about which we know very little. The natural history . . .</description><subject>Adolescent</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphangiomyoma - therapy</subject><subject>Male</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j0tLw0AUhQdRaqz-AhG6cSXRe-eRmVlKqS-ibrIPk-SOpnSakomL_nsjKa7EszmLw3fgY-wS4RZBZXdvq5dXtBZBgxRcAaI6YgkqIVIpITtmCQA3qdRWnLKzGNcwBqWdsRkHmWlUCbsuenJDoO2w6Pwi34fdp9t-tN2G2i7su-CGLrbxnJ14t4l0ceg5Kx5WxfIpzd8fn5f3eVpzo4fU6owjkgMErpzzRkiDpGqytWykVVRr1J6UbypDWvPKuwakMgKMV40Vcyam27rvYuzJl7u-Da7flwjlj3L5h_JIXU3U7qsK1PwyB8dxv5n2EGK5pXX49-0bRDBc-w</recordid><startdate>19910704</startdate><enddate>19910704</enddate><creator>Goodenberger, Daniel M</creator><creator>Dhand, Sandeep</creator><creator>Eliasson, Arn H</creator><creator>Phillips, Yancy Y</creator><creator>Tenholder, Michael F</creator><creator>Goodwin, Thomas Murphy</creator><creator>Zahner, Johannes</creator><creator>Borst, Mathias M</creator><creator>Worth, Heinrich</creator><creator>Raffin, Thomas A</creator><creator>Taylor, James R</creator><creator>Ryu, Jay</creator><creator>Colby, Thomas V</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910704</creationdate><title>Treatment of Lymphangioleiomyomatosis</title><author>Goodenberger, Daniel M ; Dhand, Sandeep ; Eliasson, Arn H ; Phillips, Yancy Y ; Tenholder, Michael F ; Goodwin, Thomas Murphy ; Zahner, Johannes ; Borst, Mathias M ; Worth, Heinrich ; Raffin, Thomas A ; Taylor, James R ; Ryu, Jay ; Colby, Thomas V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-976211ea01025aaf83481e5ce9c4d495ec717fe5fdb8e772bfad0458308f5d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphangiomyoma - therapy</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodenberger, Daniel M</creatorcontrib><creatorcontrib>Dhand, Sandeep</creatorcontrib><creatorcontrib>Eliasson, Arn H</creatorcontrib><creatorcontrib>Phillips, Yancy Y</creatorcontrib><creatorcontrib>Tenholder, Michael F</creatorcontrib><creatorcontrib>Goodwin, Thomas Murphy</creatorcontrib><creatorcontrib>Zahner, Johannes</creatorcontrib><creatorcontrib>Borst, Mathias M</creatorcontrib><creatorcontrib>Worth, Heinrich</creatorcontrib><creatorcontrib>Raffin, Thomas A</creatorcontrib><creatorcontrib>Taylor, James R</creatorcontrib><creatorcontrib>Ryu, Jay</creatorcontrib><creatorcontrib>Colby, Thomas V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodenberger, Daniel M</au><au>Dhand, Sandeep</au><au>Eliasson, Arn H</au><au>Phillips, Yancy Y</au><au>Tenholder, Michael F</au><au>Goodwin, Thomas Murphy</au><au>Zahner, Johannes</au><au>Borst, Mathias M</au><au>Worth, Heinrich</au><au>Raffin, Thomas A</au><au>Taylor, James R</au><au>Ryu, Jay</au><au>Colby, Thomas V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Lymphangioleiomyomatosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-07-04</date><risdate>1991</risdate><volume>325</volume><issue>1</issue><spage>63</spage><epage>64</epage><pages>63-64</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
The article on lymphangioleiomyomatosis (LAM) by Taylor et al. (Nov. 1 issue)* was a very useful addition to the limited literature on the disease. I take issue with one of their recommendations, however. Despite their own finding that oophorectomy is not associated with an observable clinical benefit, they continue to recommend it as second-line therapy because studies to date cannot exclude a possible benefit. Perhaps the following hypothetical encounter with a patient will illustrate my point.
"Mr. Jones, your open-lung biopsy showed a form of interstitial lung disease about which we know very little. The natural history . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>2046715</pmid><doi>10.1056/NEJM199107043250115</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-07, Vol.325 (1), p.63-64 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_crossref_primary_10_1056_NEJM199107043250115 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Combined Modality Therapy Female Humans Lymphangiomyoma - therapy Male |
| title | Treatment of Lymphangioleiomyomatosis |
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