Colonic Ulceration and Bleeding during Diclofenac Therapy
To the Editor: Diclofenac (Voltaren) is a recently introduced anti-inflammatory agent that is formulated as an enteric-coated product. We report the development of colonic ulcerations after the initiation of diclofenac therapy in two patients who were also taking other drugs. A 60-year-old woman was...
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| Veröffentlicht in: | The New England journal of medicine 1990-07, Vol.323 (2), p.135-135 |
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| container_title | The New England journal of medicine |
| container_volume | 323 |
| creator | Carson, J Notis, W M Orris, E S |
| description | To the Editor:
Diclofenac (Voltaren) is a recently introduced anti-inflammatory agent that is formulated as an enteric-coated product. We report the development of colonic ulcerations after the initiation of diclofenac therapy in two patients who were also taking other drugs.
A 60-year-old woman was prescribed diclofenac (50 mg three times daily) for osteoarthritis. Her other medications were chlorpropamide, triamterene—hydrochlorothiazide, clonidine, amitriptyline, and ferrous sulfate. After four months of diclofenac therapy, she was noted to have positive stool tests for occult blood, and her hematocrit had decreased from 0.37 to 0.29. Esophagogastroduodenoscopy revealed minimal antral gastritis. Colonoscopy showed an ulcer in . . . |
| doi_str_mv | 10.1056/NEJM199007123230216 |
| format | Article |
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Diclofenac (Voltaren) is a recently introduced anti-inflammatory agent that is formulated as an enteric-coated product. We report the development of colonic ulcerations after the initiation of diclofenac therapy in two patients who were also taking other drugs.
A 60-year-old woman was prescribed diclofenac (50 mg three times daily) for osteoarthritis. Her other medications were chlorpropamide, triamterene—hydrochlorothiazide, clonidine, amitriptyline, and ferrous sulfate. After four months of diclofenac therapy, she was noted to have positive stool tests for occult blood, and her hematocrit had decreased from 0.37 to 0.29. Esophagogastroduodenoscopy revealed minimal antral gastritis. Colonoscopy showed an ulcer in . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199007123230216</identifier><identifier>PMID: 2359424</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Colonic Diseases - chemically induced ; Diclofenac - administration & dosage ; Diclofenac - adverse effects ; Female ; Gastrointestinal Hemorrhage - chemically induced ; Humans ; Middle Aged ; Tablets, Enteric-Coated ; Ulcer - chemically induced</subject><ispartof>The New England journal of medicine, 1990-07, Vol.323 (2), p.135-135</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-e67dd17bff116d184e52a3cd2d98fca35ba3541d6c315595cc3dd34d44bbf78a3</citedby><cites>FETCH-LOGICAL-c373t-e67dd17bff116d184e52a3cd2d98fca35ba3541d6c315595cc3dd34d44bbf78a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199007123230216$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199007123230216$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2359424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carson, J</creatorcontrib><creatorcontrib>Notis, W M</creatorcontrib><creatorcontrib>Orris, E S</creatorcontrib><title>Colonic Ulceration and Bleeding during Diclofenac Therapy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Diclofenac (Voltaren) is a recently introduced anti-inflammatory agent that is formulated as an enteric-coated product. We report the development of colonic ulcerations after the initiation of diclofenac therapy in two patients who were also taking other drugs.
A 60-year-old woman was prescribed diclofenac (50 mg three times daily) for osteoarthritis. Her other medications were chlorpropamide, triamterene—hydrochlorothiazide, clonidine, amitriptyline, and ferrous sulfate. After four months of diclofenac therapy, she was noted to have positive stool tests for occult blood, and her hematocrit had decreased from 0.37 to 0.29. Esophagogastroduodenoscopy revealed minimal antral gastritis. Colonoscopy showed an ulcer in . . .</description><subject>Aged</subject><subject>Colonic Diseases - chemically induced</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - adverse effects</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - chemically induced</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Tablets, Enteric-Coated</subject><subject>Ulcer - chemically induced</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EKqHwCxBS7ijg9dpJfIS2vFTg0p4jx2tDqryUtIf-e1Kl4oRYaTWH2W-kHcaugd8BV_H9x-LtHbTmPAGBArmA-IQFoBAjKXl8ygLORRrJROM5u-j7DR8GpJ6wiUClpZAB07OmbOrChuvSus5si6YOTU3hY-kcFfVXSLvuIPPClo13tbHh6ns4bPeX7MybsndXR52y9dNiNXuJlp_Pr7OHZWQxwW3k4oQIktx7gJgglU4Jg5YE6dRbgyofVgLFFkEpraxFIpQkZZ77JDU4ZTjm2q7p-875rO2KynT7DHh26CH7o4eBuhmpdpdXjn6Z4-ODfzv6VdVntdtU_6b9AGmTZEY</recordid><startdate>19900712</startdate><enddate>19900712</enddate><creator>Carson, J</creator><creator>Notis, W M</creator><creator>Orris, E S</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19900712</creationdate><title>Colonic Ulceration and Bleeding during Diclofenac Therapy</title><author>Carson, J ; Notis, W M ; Orris, E S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-e67dd17bff116d184e52a3cd2d98fca35ba3541d6c315595cc3dd34d44bbf78a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aged</topic><topic>Colonic Diseases - chemically induced</topic><topic>Diclofenac - administration & dosage</topic><topic>Diclofenac - adverse effects</topic><topic>Female</topic><topic>Gastrointestinal Hemorrhage - chemically induced</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Tablets, Enteric-Coated</topic><topic>Ulcer - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carson, J</creatorcontrib><creatorcontrib>Notis, W M</creatorcontrib><creatorcontrib>Orris, E S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carson, J</au><au>Notis, W M</au><au>Orris, E S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colonic Ulceration and Bleeding during Diclofenac Therapy</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1990-07-12</date><risdate>1990</risdate><volume>323</volume><issue>2</issue><spage>135</spage><epage>135</epage><pages>135-135</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Diclofenac (Voltaren) is a recently introduced anti-inflammatory agent that is formulated as an enteric-coated product. We report the development of colonic ulcerations after the initiation of diclofenac therapy in two patients who were also taking other drugs.
A 60-year-old woman was prescribed diclofenac (50 mg three times daily) for osteoarthritis. Her other medications were chlorpropamide, triamterene—hydrochlorothiazide, clonidine, amitriptyline, and ferrous sulfate. After four months of diclofenac therapy, she was noted to have positive stool tests for occult blood, and her hematocrit had decreased from 0.37 to 0.29. Esophagogastroduodenoscopy revealed minimal antral gastritis. Colonoscopy showed an ulcer in . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>2359424</pmid><doi>10.1056/NEJM199007123230216</doi><tpages>1</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 1990-07, Vol.323 (2), p.135-135 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Aged Colonic Diseases - chemically induced Diclofenac - administration & dosage Diclofenac - adverse effects Female Gastrointestinal Hemorrhage - chemically induced Humans Middle Aged Tablets, Enteric-Coated Ulcer - chemically induced |
| title | Colonic Ulceration and Bleeding during Diclofenac Therapy |
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