Asymmetric Synthesis of the Diene Unit of Methyl Sartortuoate via a Temperature-Sensitive Intramolecular Horner-Wadsworth-Emmons (HWE) Reaction
Abstract The asymmetric synthesis of the diene unit of methyl sartortuoate is described. A temperature-sensitive intramolecular Horner-Wadsworth-Emmons reaction was employed for the construction of the 14-membered ring. A Payne rearrangement of an 2,3-epoxy alcohol was utilized for the installation...
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| Veröffentlicht in: | Synlett 2007-03, Vol.2007 (4), p.0571-0574 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
The asymmetric synthesis of the diene unit of methyl sartortuoate is described. A temperature-sensitive intramolecular Horner-Wadsworth-Emmons reaction was employed for the construction of the 14-membered ring. A Payne rearrangement of an 2,3-epoxy alcohol was utilized for the installation of the hydroxyl group at the C14 position of the diene unit. |
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| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2007-967970 |