Bradycardia Due to Biperiden

Abstract In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia. The heart rate was back to normal with...

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Veröffentlicht in:	Pharmacopsychiatry 1989-01, Vol.22 (1), p.42-43
Hauptverfasser:	Aldenhövel, H. Große, Heusler, H., Gallenkamp, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biperiden - adverse effects Biperiden - therapeutic use Cardiovascular Diseases - chemically induced Cardiovascular Diseases - physiopathology Case Report Drug toxicity and drugs side effects treatment Heart Rate - drug effects Humans Male Medical sciences Neuralgia - drug therapy Pharmacology. Drug treatments Piperidines - adverse effects Toxicity: cardiovascular system
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Zusammenfassung:	Abstract In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia. The heart rate was back to normal within 12 hours upon administration of orciprenaline under cardiac monitoring in an intensive care unit. Bradycardia induced by biperiden is attributed to the speed of injection and to a dose-related dual effect of atropine-like drugs on muscarine receptors..
ISSN:	0176-3679 1439-0795
DOI:	10.1055/s-2007-1014576