Ritanserin Reduces Abuse of Alcohol, Cocaine, and Fentanyl in Rats
Abstract Rats that had received 3 % alcohol, 0.01 % cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin...
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| Veröffentlicht in: | Pharmacopsychiatry 1991-09, Vol.24 (5), p.159-163 |
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| container_start_page | 159 |
| container_title | Pharmacopsychiatry |
| container_volume | 24 |
| creator | Meert, T. F. Awouters, F. Niemegeers, C. J. E. Schellekens, K. H. L. Janssen, P. A. J. |
| description | Abstract
Rats that had received 3 % alcohol, 0.01 % cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT
2
antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs. |
| doi_str_mv | 10.1055/s-2007-1014461 |
| format | Article |
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Rats that had received 3 % alcohol, 0.01 % cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT
2
antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs.</description><identifier>ISSN: 0176-3679</identifier><identifier>EISSN: 1439-0795</identifier><identifier>DOI: 10.1055/s-2007-1014461</identifier><identifier>PMID: 1775520</identifier><identifier>CODEN: PHRMEZ</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Cocaine ; Drinking - drug effects ; Ethanol ; Fentanyl ; Male ; Medical sciences ; Rats ; Rats, Inbred Strains ; Ritanserin - therapeutic use ; Substance-Related Disorders - drug therapy ; Toxicology</subject><ispartof>Pharmacopsychiatry, 1991-09, Vol.24 (5), p.159-163</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-6efe236ad16d74829d9bcd57af2025ec7a26200c633bfb2ae50d6d0c7b4133b43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1014461.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4317768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1775520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meert, T. F.</creatorcontrib><creatorcontrib>Awouters, F.</creatorcontrib><creatorcontrib>Niemegeers, C. J. E.</creatorcontrib><creatorcontrib>Schellekens, K. H. L.</creatorcontrib><creatorcontrib>Janssen, P. A. J.</creatorcontrib><title>Ritanserin Reduces Abuse of Alcohol, Cocaine, and Fentanyl in Rats</title><title>Pharmacopsychiatry</title><addtitle>Pharmacopsychiatry</addtitle><description>Abstract
Rats that had received 3 % alcohol, 0.01 % cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT
2
antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Drinking - drug effects</subject><subject>Ethanol</subject><subject>Fentanyl</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Ritanserin - therapeutic use</subject><subject>Substance-Related Disorders - drug therapy</subject><subject>Toxicology</subject><issn>0176-3679</issn><issn>1439-0795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LAzEQxYMotVav3oQcPDY1H5uke6ylVaEgFD2HbDKhW7a7ZbN76H9vyhY9eRqY93szvIfQI6MzRqV8iYRTqgmjLMsUu0JjlomcUJ3LazSmTCsilM5v0V2Me5qgnIoRGjGtpeR0jF63ZWfrCG1Z4y343kHEi6KPgJuAF5Vrdk01xcvG2bKGKba1x2uok-VU4bPFdvEe3QRbRXi4zAn6Xq--lu9k8_n2sVxsiBNSd0RBAC6U9Ux5nc157vPCealt4JRLcNpylaI4JUQRCm5BUq88dbrIWFplYoJmw13XNjG2EMyxLQ-2PRlGzbkLE825C3PpIhmeBsOxLw7g__AhfNKfL7qNzlahtbUr4y-WiQSqecLIgHW7Eg5g9k3f1inof29_AMAZctw</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>Meert, T. F.</creator><creator>Awouters, F.</creator><creator>Niemegeers, C. J. E.</creator><creator>Schellekens, K. H. L.</creator><creator>Janssen, P. A. J.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910901</creationdate><title>Ritanserin Reduces Abuse of Alcohol, Cocaine, and Fentanyl in Rats</title><author>Meert, T. F. ; Awouters, F. ; Niemegeers, C. J. E. ; Schellekens, K. H. L. ; Janssen, P. A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-6efe236ad16d74829d9bcd57af2025ec7a26200c633bfb2ae50d6d0c7b4133b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cocaine</topic><topic>Drinking - drug effects</topic><topic>Ethanol</topic><topic>Fentanyl</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Ritanserin - therapeutic use</topic><topic>Substance-Related Disorders - drug therapy</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meert, T. F.</creatorcontrib><creatorcontrib>Awouters, F.</creatorcontrib><creatorcontrib>Niemegeers, C. J. E.</creatorcontrib><creatorcontrib>Schellekens, K. H. L.</creatorcontrib><creatorcontrib>Janssen, P. A. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pharmacopsychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meert, T. F.</au><au>Awouters, F.</au><au>Niemegeers, C. J. E.</au><au>Schellekens, K. H. L.</au><au>Janssen, P. A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ritanserin Reduces Abuse of Alcohol, Cocaine, and Fentanyl in Rats</atitle><jtitle>Pharmacopsychiatry</jtitle><addtitle>Pharmacopsychiatry</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>24</volume><issue>5</issue><spage>159</spage><epage>163</epage><pages>159-163</pages><issn>0176-3679</issn><eissn>1439-0795</eissn><coden>PHRMEZ</coden><abstract>Abstract
Rats that had received 3 % alcohol, 0.01 % cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT
2
antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>1775520</pmid><doi>10.1055/s-2007-1014461</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0176-3679 |
| ispartof | Pharmacopsychiatry, 1991-09, Vol.24 (5), p.159-163 |
| issn | 0176-3679 1439-0795 |
| language | eng |
| recordid | cdi_crossref_primary_10_1055_s_2007_1014461 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Cocaine Drinking - drug effects Ethanol Fentanyl Male Medical sciences Rats Rats, Inbred Strains Ritanserin - therapeutic use Substance-Related Disorders - drug therapy Toxicology |
| title | Ritanserin Reduces Abuse of Alcohol, Cocaine, and Fentanyl in Rats |
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