Activation of Blood Coagulation and Fibrinolysis in Graves' Disease
Summary We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or 131 I. Fibrinopeptide A and Bβ 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected...
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| Veröffentlicht in: | Hormone and metabolic research 1991-12, Vol.23 (12), p.609-611 |
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| container_title | Hormone and metabolic research |
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| creator | Marongiu, F. Conti, M. Murtas, M. L. Mameli, G. Sorano, G. G. Martino, E. |
| description | Summary
We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or
131
I.
Fibrinopeptide A and Bβ 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and Bβ 15-42 were higher in patients than in controls (p < 0.0001). There was no difference in fibrinopeptide A nor in Bβ 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and Bβ 15-42 after treatment. |
| doi_str_mv | 10.1055/s-2007-1003766 |
| format | Article |
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We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or
131
I.
Fibrinopeptide A and Bβ 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and Bβ 15-42 were higher in patients than in controls (p < 0.0001). There was no difference in fibrinopeptide A nor in Bβ 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and Bβ 15-42 after treatment.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1003766</identifier><identifier>PMID: 1778596</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Blood Coagulation ; Clinical ; Endocrinopathies ; Female ; Fibrin Fibrinogen Degradation Products ; Fibrinogen - metabolism ; Fibrinolysis ; Fibrinopeptide A - metabolism ; Fibrinopeptide B - metabolism ; Graves Disease - blood ; Graves Disease - drug therapy ; Graves Disease - radiotherapy ; Humans ; Iodine Radioisotopes - therapeutic use ; Male ; Medical sciences ; Methimazole - therapeutic use ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Peptide Fragments - metabolism ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Hormone and metabolic research, 1991-12, Vol.23 (12), p.609-611</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-ceb8397f8fadb89337f6dabf824d56d87a92fc565ec87a3e2af8aea0b0495e343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1003766.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5112224$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1778596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marongiu, F.</creatorcontrib><creatorcontrib>Conti, M.</creatorcontrib><creatorcontrib>Murtas, M. L.</creatorcontrib><creatorcontrib>Mameli, G.</creatorcontrib><creatorcontrib>Sorano, G. G.</creatorcontrib><creatorcontrib>Martino, E.</creatorcontrib><title>Activation of Blood Coagulation and Fibrinolysis in Graves' Disease</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or
131
I.
Fibrinopeptide A and Bβ 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and Bβ 15-42 were higher in patients than in controls (p < 0.0001). There was no difference in fibrinopeptide A nor in Bβ 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and Bβ 15-42 after treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation</subject><subject>Clinical</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products</subject><subject>Fibrinogen - metabolism</subject><subject>Fibrinolysis</subject><subject>Fibrinopeptide A - metabolism</subject><subject>Fibrinopeptide B - metabolism</subject><subject>Graves Disease - blood</subject><subject>Graves Disease - drug therapy</subject><subject>Graves Disease - radiotherapy</subject><subject>Humans</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methimazole - therapeutic use</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Peptide Fragments - metabolism</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UD1PwzAUtBColMLKhpQBicnFn4kzlkALUiUWmKMXxwZXaVzZSaX-e1Klgonpfdzde7pD6JaSOSVSPkbMCMkwJYRnaXqGplTwHAum0nM0JYQqLIngl-gqxs0wipyKCZrQLFMyT6eoWOjO7aFzvk28TZ4a7-uk8PDVN-MS2jpZuiq41jeH6GLi2mQVYG_iQ_LsooFortGFhSaam1Odoc_ly0fxitfvq7discZaMN5hbSrF88wqC3Wlcs4zm9ZQWcVELdNaZZAzq2UqjR56bhhYBQZIRUQuDRd8hubjXR18jMHYchfcFsKhpKQ8hlHG8hhGeQpjENyNgl1fbU39Rx_dD_j9CYeoobEBWu3iL01Syhg7_sUjrft2ZmvKje9DOxj97-0P0sZ0zg</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Marongiu, F.</creator><creator>Conti, M.</creator><creator>Murtas, M. L.</creator><creator>Mameli, G.</creator><creator>Sorano, G. G.</creator><creator>Martino, E.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19911201</creationdate><title>Activation of Blood Coagulation and Fibrinolysis in Graves' Disease</title><author>Marongiu, F. ; Conti, M. ; Murtas, M. L. ; Mameli, G. ; Sorano, G. G. ; Martino, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-ceb8397f8fadb89337f6dabf824d56d87a92fc565ec87a3e2af8aea0b0495e343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation</topic><topic>Clinical</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products</topic><topic>Fibrinogen - metabolism</topic><topic>Fibrinolysis</topic><topic>Fibrinopeptide A - metabolism</topic><topic>Fibrinopeptide B - metabolism</topic><topic>Graves Disease - blood</topic><topic>Graves Disease - drug therapy</topic><topic>Graves Disease - radiotherapy</topic><topic>Humans</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methimazole - therapeutic use</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Peptide Fragments - metabolism</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marongiu, F.</creatorcontrib><creatorcontrib>Conti, M.</creatorcontrib><creatorcontrib>Murtas, M. L.</creatorcontrib><creatorcontrib>Mameli, G.</creatorcontrib><creatorcontrib>Sorano, G. G.</creatorcontrib><creatorcontrib>Martino, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marongiu, F.</au><au>Conti, M.</au><au>Murtas, M. L.</au><au>Mameli, G.</au><au>Sorano, G. G.</au><au>Martino, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of Blood Coagulation and Fibrinolysis in Graves' Disease</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>23</volume><issue>12</issue><spage>609</spage><epage>611</epage><pages>609-611</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or
131
I.
Fibrinopeptide A and Bβ 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and Bβ 15-42 were higher in patients than in controls (p < 0.0001). There was no difference in fibrinopeptide A nor in Bβ 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and Bβ 15-42 after treatment.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>1778596</pmid><doi>10.1055/s-2007-1003766</doi><tpages>3</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 1991-12, Vol.23 (12), p.609-611 |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Blood Coagulation Clinical Endocrinopathies Female Fibrin Fibrinogen Degradation Products Fibrinogen - metabolism Fibrinolysis Fibrinopeptide A - metabolism Fibrinopeptide B - metabolism Graves Disease - blood Graves Disease - drug therapy Graves Disease - radiotherapy Humans Iodine Radioisotopes - therapeutic use Male Medical sciences Methimazole - therapeutic use Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Peptide Fragments - metabolism Thyroid. Thyroid axis (diseases) |
| title | Activation of Blood Coagulation and Fibrinolysis in Graves' Disease |
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