Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy
Summary Mild streptozotocin diabetic rats, characterized by normal or slighty elevated fasting blood glucose levels and glucose intolerance, treated with excessive doses of monocomponent pork insulin (0.5 U/day) (I) or glybenclamide (0.6 mg/day) (S) were compared to controls (C) and streptozotocin-d...
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| Veröffentlicht in: | Hormone and metabolic research 1993-09, Vol.25 (9), p.457-461 |
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| creator | Ursich, Mileni J. M. Fukui, Rosa T. Rocha, Dalva M. Silva, Maria E. R. Wajchenberg, B. L. |
| description | Summary
Mild streptozotocin diabetic rats, characterized by normal or slighty elevated fasting blood glucose levels and glucose intolerance, treated with excessive doses of monocomponent pork insulin (0.5 U/day) (I) or glybenclamide (0.6 mg/day) (S) were compared to controls (C) and streptozotocin-diabetic rats without treatment (D). Intravenous glucose tolerance tests (0.75 g/kg) were performed in all animals and repeated after overtreatment. Insulin binding and insulin-induced D-(U-
14
C)-glucose transport and oxidation were also determined in isolated epididymal adipocytes. Diabetic rats showed a failure in the initial phase of insulin release and glucose intolerance as compared with (C). In overtreated rats glucose tolerance worsened (p |
| doi_str_mv | 10.1055/s-2007-1002148 |
| format | Article |
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Mild streptozotocin diabetic rats, characterized by normal or slighty elevated fasting blood glucose levels and glucose intolerance, treated with excessive doses of monocomponent pork insulin (0.5 U/day) (I) or glybenclamide (0.6 mg/day) (S) were compared to controls (C) and streptozotocin-diabetic rats without treatment (D). Intravenous glucose tolerance tests (0.75 g/kg) were performed in all animals and repeated after overtreatment. Insulin binding and insulin-induced D-(U-
14
C)-glucose transport and oxidation were also determined in isolated epididymal adipocytes. Diabetic rats showed a failure in the initial phase of insulin release and glucose intolerance as compared with (C). In overtreated rats glucose tolerance worsened (p<0.05) after therapy. Maximal insulin binding by isolated adipocytes at tracer insulin concentration was unchanged after excessive insulin or sulfonylurea therapy. Besides, glucose transport and oxidation in the cells of overtreated rats were greater than in D and even greater than in C. These apparently divergent results, i.e. deterioration of glucose tolerance with increased insulin action in adipocytes suggest that overtreatment induces a state of resistance to hormone action in other target tissue(s) than the adipose one, possibly muscle.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1002148</identifier><identifier>PMID: 8225197</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adipocytes - drug effects ; Adipocytes - metabolism ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Weight - drug effects ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Glucose Intolerance - blood ; Glucose Tolerance Test ; Hormones. Endocrine system ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - therapeutic use ; Insulin - adverse effects ; Insulin - blood ; Insulin - therapeutic use ; Iodine Radioisotopes ; Male ; Medical sciences ; Originals Basic ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Sulfonylurea Compounds - adverse effects ; Sulfonylurea Compounds - therapeutic use ; Swine</subject><ispartof>Hormone and metabolic research, 1993-09, Vol.25 (9), p.457-461</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f0ef49b80cc3431d883a5e7f59f597da58d8c7797f013b4412ce3cf6c24ac40f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1002148.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4856297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8225197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ursich, Mileni J. M.</creatorcontrib><creatorcontrib>Fukui, Rosa T.</creatorcontrib><creatorcontrib>Rocha, Dalva M.</creatorcontrib><creatorcontrib>Silva, Maria E. R.</creatorcontrib><creatorcontrib>Wajchenberg, B. L.</creatorcontrib><title>Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
Mild streptozotocin diabetic rats, characterized by normal or slighty elevated fasting blood glucose levels and glucose intolerance, treated with excessive doses of monocomponent pork insulin (0.5 U/day) (I) or glybenclamide (0.6 mg/day) (S) were compared to controls (C) and streptozotocin-diabetic rats without treatment (D). Intravenous glucose tolerance tests (0.75 g/kg) were performed in all animals and repeated after overtreatment. Insulin binding and insulin-induced D-(U-
14
C)-glucose transport and oxidation were also determined in isolated epididymal adipocytes. Diabetic rats showed a failure in the initial phase of insulin release and glucose intolerance as compared with (C). In overtreated rats glucose tolerance worsened (p<0.05) after therapy. Maximal insulin binding by isolated adipocytes at tracer insulin concentration was unchanged after excessive insulin or sulfonylurea therapy. Besides, glucose transport and oxidation in the cells of overtreated rats were greater than in D and even greater than in C. These apparently divergent results, i.e. deterioration of glucose tolerance with increased insulin action in adipocytes suggest that overtreatment induces a state of resistance to hormone action in other target tissue(s) than the adipose one, possibly muscle.</description><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight - drug effects</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Tolerance Test</subject><subject>Hormones. Endocrine system</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - adverse effects</subject><subject>Insulin - blood</subject><subject>Insulin - therapeutic use</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Originals Basic</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfonylurea Compounds - adverse effects</subject><subject>Sulfonylurea Compounds - therapeutic use</subject><subject>Swine</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotVav3oQ9eE3NZ5M9Slu1UPFgPYdsNrFbttmS7Er7703t0pswMMzM-84wDwD3GI0x4vwpQoKQgBghgpm8AEPMaA4ZkZNLMEQIS8gRo9fgJsZNKlmO2QAMJCEc52IIZu-21UVTVyab2aD9t91a38as8tl8b2yM1Y_NFj52depoX2afXe0af6i7YHW2WifP7nALrpyuo73r8wh8vcxX0ze4_HhdTJ-X0FAuWuiQdSwvJDKGMopLKanmVjiepxCl5rKURohcOIRpwRgmxlLjJoYwbRhydATGp70mNDEG69QuVFsdDgojdaShojrSUD2NZHg4GXZdsbXlWd6_n-aP_VxHo2uXAJgqnmVM8gn5k8GTrF1XiY_aNF3w6dH_zv4Ci1V1Jw</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Ursich, Mileni J. M.</creator><creator>Fukui, Rosa T.</creator><creator>Rocha, Dalva M.</creator><creator>Silva, Maria E. R.</creator><creator>Wajchenberg, B. L.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19930901</creationdate><title>Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy</title><author>Ursich, Mileni J. M. ; Fukui, Rosa T. ; Rocha, Dalva M. ; Silva, Maria E. R. ; Wajchenberg, B. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f0ef49b80cc3431d883a5e7f59f597da58d8c7797f013b4412ce3cf6c24ac40f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight - drug effects</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Tolerance Test</topic><topic>Hormones. Endocrine system</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - adverse effects</topic><topic>Insulin - blood</topic><topic>Insulin - therapeutic use</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Originals Basic</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sulfonylurea Compounds - adverse effects</topic><topic>Sulfonylurea Compounds - therapeutic use</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ursich, Mileni J. M.</creatorcontrib><creatorcontrib>Fukui, Rosa T.</creatorcontrib><creatorcontrib>Rocha, Dalva M.</creatorcontrib><creatorcontrib>Silva, Maria E. R.</creatorcontrib><creatorcontrib>Wajchenberg, B. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ursich, Mileni J. M.</au><au>Fukui, Rosa T.</au><au>Rocha, Dalva M.</au><au>Silva, Maria E. R.</au><au>Wajchenberg, B. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>25</volume><issue>9</issue><spage>457</spage><epage>461</epage><pages>457-461</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
Mild streptozotocin diabetic rats, characterized by normal or slighty elevated fasting blood glucose levels and glucose intolerance, treated with excessive doses of monocomponent pork insulin (0.5 U/day) (I) or glybenclamide (0.6 mg/day) (S) were compared to controls (C) and streptozotocin-diabetic rats without treatment (D). Intravenous glucose tolerance tests (0.75 g/kg) were performed in all animals and repeated after overtreatment. Insulin binding and insulin-induced D-(U-
14
C)-glucose transport and oxidation were also determined in isolated epididymal adipocytes. Diabetic rats showed a failure in the initial phase of insulin release and glucose intolerance as compared with (C). In overtreated rats glucose tolerance worsened (p<0.05) after therapy. Maximal insulin binding by isolated adipocytes at tracer insulin concentration was unchanged after excessive insulin or sulfonylurea therapy. Besides, glucose transport and oxidation in the cells of overtreated rats were greater than in D and even greater than in C. These apparently divergent results, i.e. deterioration of glucose tolerance with increased insulin action in adipocytes suggest that overtreatment induces a state of resistance to hormone action in other target tissue(s) than the adipose one, possibly muscle.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>8225197</pmid><doi>10.1055/s-2007-1002148</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adipocytes - drug effects Adipocytes - metabolism Animals Biological and medical sciences Blood Glucose - metabolism Body Weight - drug effects Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Glucose Intolerance - blood Glucose Tolerance Test Hormones. Endocrine system Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin - adverse effects Insulin - blood Insulin - therapeutic use Iodine Radioisotopes Male Medical sciences Originals Basic Oxidation-Reduction Pharmacology. Drug treatments Rats Rats, Wistar Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - therapeutic use Swine |
| title | Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy |
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