A Simple Procedure for the Synthesis of 4-Aza-podophyllotoxin Derivatives in Water under Microwave Irradiation Conditions
Abstract 4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced envir...
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Veröffentlicht in: | Synlett 2006-10, Vol.2006 (17), p.2785-2790 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract
4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced environmental impact, and convenient procedure. |
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ISSN: | 0936-5214 1437-2096 |
DOI: | 10.1055/s-2006-950279 |