A Simple Procedure for the Synthesis of 4-Aza-podophyllotoxin Derivatives in Water under Microwave Irradiation Conditions

Abstract 4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced envir...

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Veröffentlicht in:Synlett 2006-10, Vol.2006 (17), p.2785-2790
Hauptverfasser: Tu, Shujiang, Zhang, Yan, Zhang, Junyong, Jiang, Bo, Jia, Runhong, Zhang, Jinpeng, Ji, Shunjun
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Sprache:eng
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Zusammenfassung:Abstract 4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced environmental impact, and ­convenient procedure.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-950279