Antiparasitic Activity of Some Xanthones and Biflavonoids and Identification of a New Biflavanoid from the Root Bark of Garcinia livingstonei

Antiparasitic Activity of Some Xanthones and Biflavonoids and Identification of a New Biflavanoid from the Root Bark of Garcinia livingstonei

A new biflavanoid, ent -naringeninyl-(I-3,II-8)-4'- O -methylnaringenin ( 1 ), along with five known xanthones and two known biflavonoids, (+)-volkensiflavone and (+)-morelloflavone, was isolated from the root bark of Garcinia livingstonei (Clusiaceae) T. Anders., collected in Tanzania. The abs...

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Hauptverfasser: Pieters, L, Mbwambo, ZH, Kapingu, MC, Moshi, MJ, Machumi, F, Apers, S, Cos, P, Ferreira, D, Marais, JPJ, Vanden Berghe, D, Maes, L, Vlietinck, A
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container_issue 11
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creator Pieters, L
Mbwambo, ZH
Kapingu, MC
Moshi, MJ
Machumi, F
Apers, S
Cos, P
Ferreira, D
Marais, JPJ
Vanden Berghe, D
Maes, L
Vlietinck, A
description A new biflavanoid, ent -naringeninyl-(I-3,II-8)-4'- O -methylnaringenin ( 1 ), along with five known xanthones and two known biflavonoids, (+)-volkensiflavone and (+)-morelloflavone, was isolated from the root bark of Garcinia livingstonei (Clusiaceae) T. Anders., collected in Tanzania. The absolute configuration of 1 was established by CD spectroscopy. This compound showed a moderate activity against P. falciparum (IC 50 6.0±1.7µM). Antitrypanosomal activity (IC 50 0.87±0.23µM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9 H -xanthen-9-one. The dimeric xanthone garcilivin A showed a higher and non-selective antiparasitic activity and cytotoxicity (IC 50 2.0±0.1µM against MRC-5 cells) than its diastereoisomer garcilivin C (IC 50 52.3±5.5µM).
doi_str_mv 10.1055/s-2006-949803
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title Antiparasitic Activity of Some Xanthones and Biflavonoids and Identification of a New Biflavanoid from the Root Bark of Garcinia livingstonei
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