In Vitro 12(S)-HETE and Leukotriene Metabolism Inhibitory Activity of Sesquiterpenes of Warburgia ugandensis

Abstract Twelve drimane and coloratane sesquiterpenes, isolated from the stem bark of Ethiopian WARBURGIA UGANDENSIS, were evaluated for inhibition of 12(S)-HETE using human platelets and of leukotriene B 4 formation using activated human neutrophile granulocytes. Among the compounds examined for in...

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Veröffentlicht in:	Planta medica 2006-06, Vol.72 (8), p.754-756
Hauptverfasser:	Wube, A.A, Gibbons, S, Asres, K, Streit, B, Adams, M, Bauer, R, Bucar, F
Format:	Artikel
Sprache:	eng
Schlagworte:	12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - antagonists & inhibitors arachidonic acid Biological and medical sciences Blood Platelets - metabolism Canellaceae chemical constituents of plants chemical structure enzyme inhibition Free Radical Scavengers - administration & dosage Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use General pharmacology Humans Inhibitory Concentration 50 Letter Leukotriene B4 - biosynthesis leukotrienes Leukotrienes - metabolism lipoxygenase Magnoliopsida Medical sciences muzigadial Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Stems Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use sesquiterpenoids ugandensidial Warburgia ugandensis
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