Up regulation of CYP1B1 is an early event in gastro-oesophageal reflux mediated oesophageal injury
Background: Cytochrome P450 1B1 (CYP1B1) catalyzes activation of various carcinogens and has been implicated in early carcinogenesis in various epithelial cancers. Gastro-oesophageal reflux can potentiate malignant changes in oesophageal mucosa and it is hypothesized that CYP1B1 is up-regulated in t...
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