Semisynthetic 15-O-acyl- and 1, 15-Di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials

Abstract Among the quassinoids isolated from EURYCOMA LONGIFOLIA Jack, eurycomanone was identified as the most potent and toxic inhibitor of the chloroquine-resistant Gombak A isolate of PLASMODIUM FALCIPARUM. Several diacylated derivatives of eurycomanone, 1,15-di-O-isovaleryleurycomanone, 1,15-di-...

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Veröffentlicht in:	Planta medica 2005-10, Vol.71 (10), p.967-969
Hauptverfasser:	Chan, K.L, Choo, C.Y, Abdullah, N.R
Format:	Artikel
Sprache:	eng
Schlagworte:	acyleurycomanone Animals antimalarials Antimalarials - administration & dosage Antimalarials - chemical synthesis Antimalarials - pharmacology Antimalarials - therapeutic use Artemia - drug effects Artemia salina Biological and medical sciences Chloroquine Drug Resistance Eurycoma Eurycoma longifolia eurycomanone General pharmacology human health Humans isovaleryleurycomanone Letter Malaria, Falciparum - drug therapy Medical sciences medicinal plants Parasitic Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - chemical synthesis Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Plasmodium falciparum Plasmodium falciparum - drug effects quassinoids toxicity testing traditional medicine triterpenoids
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