Improved Synthesis of 1,3-Propanediol Derivatives Having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position: Application to Chemoenzymatic Synthesis of Novel Acyclic Nucleotide Analogues of Adenosine Bisphosphates

ABSTRACT An alternative synthesis of 1,3-propanediol 1 having a diethoxyphosphoryldifluoroethyl group was examined. The method readily provided a multi-gram quantity of 1. The propanediol 1 was chemo-enzymatically transformed to acyclic nucleotide analogues for adenosine bisphosphates.

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Veröffentlicht in:	Synthesis (Stuttgart) 2005-02, Vol.2005 (2), p.187-192
Hauptverfasser:	Murano, Tetsuo, Kobayakawa, Hirokuni, Yuasa, Yoko, Yokomatsu, Tsutomu, Shibuya, Shiroshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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