A Simple Synthesis of Gestodene from 18-Methyl-4-estren-3,17-dione

A Simple Synthesis of Gestodene from 18-Methyl-4-estren-3,17-dione

Abstract A simple synthesis enables us to obtain the progestin, gestodene, in five steps and satisfactory yields from 18-methyl-4-estren-3,17-dione. This was accomplished through the selective protection of the C-3 carbonyl group as a cyclic ketal and the installation of a phenylsulfoxide group at t...

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Veröffentlicht in:Synlett 2004-08, Vol.2004 (10), p.1838-1840
Hauptverfasser: Ferraboschi, Patrizia, Grisenti, Paride, Onofri, Andrea, Prestileo, Paolo
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A simple synthesis enables us to obtain the progestin, gestodene, in five steps and satisfactory yields from 18-methyl-4-estren-3,17-dione. This was accomplished through the selective protection of the C-3 carbonyl group as a cyclic ketal and the installation of a phenylsulfoxide group at the C-16 position.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-829070