New diarylheptanoids from the rhizomes of Dioscorea spongiosa and their antiosteoporotic activity

Abstract Bioassay-guided fractionation of the water extract of the rhizomes of DIOSCOREA SPONGIOSA led to the isolation and identification of new diarylheptanoids, diospongins A - C, together with three known lignans. Their structures, including absolute stereochemistry, were determined by analyses...

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Veröffentlicht in:	Planta medica 2004, Vol.70 (1), p.54-58
Hauptverfasser:	Yin, J, Kouda, K, Tezuka, Y, Le Tran, Q, Miyahara, T, Chen, Y, Kadota, S
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals aromatic hydrocarbons Biological and medical sciences bone resorption Bone Resorption - chemically induced Bone Resorption - metabolism bones chemical structure cultured cells diarylheptanoids Diarylheptanoids - administration & dosage Diarylheptanoids - chemistry Diarylheptanoids - pharmacology Diarylheptanoids - therapeutic use Dioscorea Dioscorea spongiosa Dioscoreaceae diospongins disease models General pharmacology heptane lignans Medical sciences medicinal plants Mice organ culture Organ Culture Techniques Original Paper osteoblasts osteoporosis Osteoporosis - physiopathology Osteoporosis - prevention & control Parathyroid Hormone Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots rhizomes spectral analysis Stereoisomerism
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