Photodynamic Therapy for Esophageal Diseases: A Clinical Update
Photodynamic therapy (PDT) is a "drug and device" therapy that combines the use of a photosensitizing agent and a photosensitizer (a drug that selectively accumulates and is preferentially retained in dysplastic or neoplastic cells). When activated by light of a specific wavelength in the...
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| Veröffentlicht in: | Endoscopy 2003-12, Vol.35 (12), p.1059-1068 |
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| container_title | Endoscopy |
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| creator | Prosst, R. L. Wolfsen, H. C. Gahlen, J. |
| description | Photodynamic therapy (PDT) is a "drug and device" therapy that combines the use of a photosensitizing agent and a photosensitizer (a drug that selectively accumulates and is preferentially retained in dysplastic or neoplastic cells). When activated by light of a specific wavelength in the presence of oxygen, the photoactive compound produces rapid cell death in the target tissue. While studied in nearly every area of medicine, PDT has been applied most extensively in the treatment of Barrett's mucosa, dysplasia, and early and advanced cancer of the esophagus. This article represents an extensive survey of literature to review the experience gained with PDT and to assess its clinical value in the management of esophageal diseases. |
| doi_str_mv | 10.1055/s-2003-44604 |
| format | Article |
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L.</creatorcontrib><creatorcontrib>Wolfsen, H. C.</creatorcontrib><creatorcontrib>Gahlen, J.</creatorcontrib><title>Photodynamic Therapy for Esophageal Diseases: A Clinical Update</title><title>Endoscopy</title><addtitle>Endoscopy</addtitle><description>Photodynamic therapy (PDT) is a "drug and device" therapy that combines the use of a photosensitizing agent and a photosensitizer (a drug that selectively accumulates and is preferentially retained in dysplastic or neoplastic cells). When activated by light of a specific wavelength in the presence of oxygen, the photoactive compound produces rapid cell death in the target tissue. While studied in nearly every area of medicine, PDT has been applied most extensively in the treatment of Barrett's mucosa, dysplasia, and early and advanced cancer of the esophagus. This article represents an extensive survey of literature to review the experience gained with PDT and to assess its clinical value in the management of esophageal diseases.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Aminolevulinic Acid - therapeutic use</subject><subject>Barrett Esophagus - diagnostic imaging</subject><subject>Barrett Esophagus - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Dihematoporphyrin Ether - therapeutic use</subject><subject>Diseases of the digestive system</subject><subject>Endosonography</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Hematoporphyrin Derivative - therapeutic use</subject><subject>Hematoporphyrin Photoradiation</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Organophosphorus Compounds - therapeutic use</subject><subject>Photochemotherapy - adverse effects</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Review</subject><issn>0013-726X</issn><issn>1438-8812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MtLw0AQBvBFFFurN8-Siydd3Wey9SKl1gcU9NCCtzDJzpqU5sFueuh_b2oLvXhaZvkxw_cRcs3ZA2daPwYqGJNUqZipEzLkShpqDBenZMgYlzQR8feAXISw2o2M6XMy4CpWRgk-JM9fRdM1dltDVebRokAP7TZyjY9moWkL-EFYRy9lQAgYnqJJNF2XdZn3n8vWQoeX5MzBOuDV4R2R5etsMX2n88-3j-lkTnPFxx1VQiirJSTIwCGMjTEOjRMGreEJQpbliYyd1FxmMbdGCJsAz5Ap6TR3sRyR-_3e3DcheHRp68sK_DblLN31kIZ010P610PPb_a83WQV2iM-BO_B7QFA6NM4D3VehqPTYiy0kb2727uuKLHCdNVsfN0H_f_sL_SwcgI</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Prosst, R. L.</creator><creator>Wolfsen, H. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prosst, R. L.</creatorcontrib><creatorcontrib>Wolfsen, H. C.</creatorcontrib><creatorcontrib>Gahlen, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prosst, R. L.</au><au>Wolfsen, H. C.</au><au>Gahlen, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic Therapy for Esophageal Diseases: A Clinical Update</atitle><jtitle>Endoscopy</jtitle><addtitle>Endoscopy</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>35</volume><issue>12</issue><spage>1059</spage><epage>1068</epage><pages>1059-1068</pages><issn>0013-726X</issn><eissn>1438-8812</eissn><coden>ENDCAM</coden><abstract>Photodynamic therapy (PDT) is a "drug and device" therapy that combines the use of a photosensitizing agent and a photosensitizer (a drug that selectively accumulates and is preferentially retained in dysplastic or neoplastic cells). When activated by light of a specific wavelength in the presence of oxygen, the photoactive compound produces rapid cell death in the target tissue. While studied in nearly every area of medicine, PDT has been applied most extensively in the treatment of Barrett's mucosa, dysplasia, and early and advanced cancer of the esophagus. This article represents an extensive survey of literature to review the experience gained with PDT and to assess its clinical value in the management of esophageal diseases.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>14648421</pmid><doi>10.1055/s-2003-44604</doi><tpages>10</tpages></addata></record> |
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| ispartof | Endoscopy, 2003-12, Vol.35 (12), p.1059-1068 |
| issn | 0013-726X 1438-8812 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adenocarcinoma - drug therapy Aminolevulinic Acid - therapeutic use Barrett Esophagus - diagnostic imaging Barrett Esophagus - drug therapy Biological and medical sciences Dihematoporphyrin Ether - therapeutic use Diseases of the digestive system Endosonography Esophageal Neoplasms - drug therapy Hematoporphyrin Derivative - therapeutic use Hematoporphyrin Photoradiation Humans Medical sciences Organophosphorus Compounds - therapeutic use Photochemotherapy - adverse effects Photosensitizing Agents - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Review |
| title | Photodynamic Therapy for Esophageal Diseases: A Clinical Update |
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