8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities
From flower buds of Aconitum carmichaeli Debx., a new alkaloid, 8-O-cinnamoylneoline, was isolated. The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD(50) value was 11.89 mg/kg (s. c.) in mice: the toxic...
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| Veröffentlicht in: | Planta medica 2003-09, Vol.69 (9), p.800-803 |
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| creator | Taki, Masanori Niitu, Kazuaki Omiya, Yuji Noguchi, Masamichi Fukuchi, Mikio Aburada, Masaki Okada, Minoru |
| description | From flower buds of Aconitum carmichaeli Debx., a new alkaloid, 8-O-cinnamoylneoline, was isolated. The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD(50) value was 11.89 mg/kg (s. c.) in mice: the toxicity was 1/30 times that of mesaconitine and 20 times that of benzoylmesaconine. Its ED(50) value was 0.86 mg/kg (s. c.) in mice using the tail pressure method: its analgesic effect was 1/40 times that of mesaconitine and 45 times that of benzoylmesaconine. Its safety margin (= LD(50)/ED(50)) was higher than that of benzoylmesaconine but lower than that of mesaconitine. |
| doi_str_mv | 10.1055/s-2003-43217 |
| format | Article |
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The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD(50) value was 11.89 mg/kg (s. c.) in mice: the toxicity was 1/30 times that of mesaconitine and 20 times that of benzoylmesaconine. Its ED(50) value was 0.86 mg/kg (s. c.) in mice using the tail pressure method: its analgesic effect was 1/40 times that of mesaconitine and 45 times that of benzoylmesaconine. Its safety margin (= LD(50)/ED(50)) was higher than that of benzoylmesaconine but lower than that of mesaconitine.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2003-43217</identifier><identifier>PMID: 14598203</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Aconitum ; alkaloids ; Alkaloids - administration & dosage ; Alkaloids - pharmacology ; Alkaloids - therapeutic use ; Alkaloids - toxicity ; analgesic effect ; Analgesics - administration & dosage ; Analgesics - pharmacology ; Analgesics - therapeutic use ; Analgesics - toxicity ; Animals ; Biological and medical sciences ; buds ; Cinnamates - administration & dosage ; Cinnamates - pharmacology ; Cinnamates - therapeutic use ; Cinnamates - toxicity ; Flowers ; General pharmacology ; Lethal Dose 50 ; Male ; margin of safety ; Medical sciences ; Mice ; Mice, Inbred Strains ; Original Paper ; Pain - prevention & control ; Pain Measurement - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; spectral analysis ; tail ; toxicity</subject><ispartof>Planta medica, 2003-09, Vol.69 (9), p.800-803</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-cafe0f73dcf8d0497da3a40cb8292446950bace4694bb41d721b7098c32270a53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2003-43217.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2003-43217$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3006,3007,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15209658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14598203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taki, Masanori</creatorcontrib><creatorcontrib>Niitu, Kazuaki</creatorcontrib><creatorcontrib>Omiya, Yuji</creatorcontrib><creatorcontrib>Noguchi, Masamichi</creatorcontrib><creatorcontrib>Fukuchi, Mikio</creatorcontrib><creatorcontrib>Aburada, Masaki</creatorcontrib><creatorcontrib>Okada, Minoru</creatorcontrib><title>8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>From flower buds of Aconitum carmichaeli Debx., a new alkaloid, 8-O-cinnamoylneoline, was isolated. The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD(50) value was 11.89 mg/kg (s. c.) in mice: the toxicity was 1/30 times that of mesaconitine and 20 times that of benzoylmesaconine. Its ED(50) value was 0.86 mg/kg (s. c.) in mice using the tail pressure method: its analgesic effect was 1/40 times that of mesaconitine and 45 times that of benzoylmesaconine. Its safety margin (= LD(50)/ED(50)) was higher than that of benzoylmesaconine but lower than that of mesaconitine.</description><subject>Aconitum</subject><subject>alkaloids</subject><subject>Alkaloids - administration & dosage</subject><subject>Alkaloids - pharmacology</subject><subject>Alkaloids - therapeutic use</subject><subject>Alkaloids - toxicity</subject><subject>analgesic effect</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Analgesics - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>buds</subject><subject>Cinnamates - administration & dosage</subject><subject>Cinnamates - pharmacology</subject><subject>Cinnamates - therapeutic use</subject><subject>Cinnamates - toxicity</subject><subject>Flowers</subject><subject>General pharmacology</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>margin of safety</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Original Paper</subject><subject>Pain - prevention & control</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>spectral analysis</subject><subject>tail</subject><subject>toxicity</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9P2zAUwHELbYKOceO8-bLTMHv-kSY-ZtW6IaFxgJ6jF8emZk6M7BTof09KK3HayX7WR8_Sl5BzDpcciuJHZgJAMiUFL4_IjCupGQjBP5DZ9C4YaCVPyKecHwC40gDH5ISrQlcC5Iy8VOyGLfwwYB-3YbAx-MFe0Jr-tc-0Dv8wRN9Rl2JPx7WlyxCfbaI_N12m0dHaxMGPm54aTL03a7TBUxw66sdM7-KLN29TPWC4t3maajP6Jz96mz-Tjw5DtmeH85Sslr_uFn_Y9c3vq0V9zYwsy5EZdBZcKTvjqg6ULjuUqMC0ldBCqbkuoEVjp4tqW8W7UvC2BF0ZKUQJWMhTcrHfa1LMOVnXPCbfY9o2HJpdwCY3u4DNW8CJf9nzx03b2-4dH4pN4NsBYDYYXMLB-PzuCgF6XlST-75349rb3jYPcZOmDPl_337da4exwfs0bVzdCuAFgIB5JSr5Cvovjo4</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Taki, Masanori</creator><creator>Niitu, Kazuaki</creator><creator>Omiya, Yuji</creator><creator>Noguchi, Masamichi</creator><creator>Fukuchi, Mikio</creator><creator>Aburada, Masaki</creator><creator>Okada, Minoru</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030901</creationdate><title>8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities</title><author>Taki, Masanori ; Niitu, Kazuaki ; Omiya, Yuji ; Noguchi, Masamichi ; Fukuchi, Mikio ; Aburada, Masaki ; Okada, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-cafe0f73dcf8d0497da3a40cb8292446950bace4694bb41d721b7098c32270a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aconitum</topic><topic>alkaloids</topic><topic>Alkaloids - administration & dosage</topic><topic>Alkaloids - pharmacology</topic><topic>Alkaloids - therapeutic use</topic><topic>Alkaloids - toxicity</topic><topic>analgesic effect</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Analgesics - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>buds</topic><topic>Cinnamates - administration & dosage</topic><topic>Cinnamates - pharmacology</topic><topic>Cinnamates - therapeutic use</topic><topic>Cinnamates - toxicity</topic><topic>Flowers</topic><topic>General pharmacology</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>margin of safety</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Original Paper</topic><topic>Pain - prevention & control</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>spectral analysis</topic><topic>tail</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taki, Masanori</creatorcontrib><creatorcontrib>Niitu, Kazuaki</creatorcontrib><creatorcontrib>Omiya, Yuji</creatorcontrib><creatorcontrib>Noguchi, Masamichi</creatorcontrib><creatorcontrib>Fukuchi, Mikio</creatorcontrib><creatorcontrib>Aburada, Masaki</creatorcontrib><creatorcontrib>Okada, Minoru</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taki, Masanori</au><au>Niitu, Kazuaki</au><au>Omiya, Yuji</au><au>Noguchi, Masamichi</au><au>Fukuchi, Mikio</au><au>Aburada, Masaki</au><au>Okada, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>69</volume><issue>9</issue><spage>800</spage><epage>803</epage><pages>800-803</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>From flower buds of Aconitum carmichaeli Debx., a new alkaloid, 8-O-cinnamoylneoline, was isolated. The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD(50) value was 11.89 mg/kg (s. c.) in mice: the toxicity was 1/30 times that of mesaconitine and 20 times that of benzoylmesaconine. Its ED(50) value was 0.86 mg/kg (s. c.) in mice using the tail pressure method: its analgesic effect was 1/40 times that of mesaconitine and 45 times that of benzoylmesaconine. Its safety margin (= LD(50)/ED(50)) was higher than that of benzoylmesaconine but lower than that of mesaconitine.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>14598203</pmid><doi>10.1055/s-2003-43217</doi><tpages>4</tpages></addata></record> |
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| subjects | Aconitum alkaloids Alkaloids - administration & dosage Alkaloids - pharmacology Alkaloids - therapeutic use Alkaloids - toxicity analgesic effect Analgesics - administration & dosage Analgesics - pharmacology Analgesics - therapeutic use Analgesics - toxicity Animals Biological and medical sciences buds Cinnamates - administration & dosage Cinnamates - pharmacology Cinnamates - therapeutic use Cinnamates - toxicity Flowers General pharmacology Lethal Dose 50 Male margin of safety Medical sciences Mice Mice, Inbred Strains Original Paper Pain - prevention & control Pain Measurement - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Extracts - toxicity spectral analysis tail toxicity |
| title | 8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities |
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