Reactivity of the Acridine Ring: One-Pot Regioselective Single and Double Bromomethylation of Acridine and Some Derivatives

Reactivity of the Acridine Ring: One-Pot Regioselective Single and Double Bromomethylation of Acridine and Some Derivatives

Abstract We report here a new efficient regioselective synthetic route to 4-bromomethylacridine and to 4,5-bis-(bromomethyl)acridine, two interesting starting materials for various 4-methyleneacridine and 4,5-bis-(methylene)acridine derivatives, in one step by direct bromomethylation of acridine wit...

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Veröffentlicht in:Synlett 2003, Vol.2003 (15), p.2349-2350
Hauptverfasser: Chiron, Julien, Galy, Jean-Pierre
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container_title Synlett
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creator Chiron, Julien
Galy, Jean-Pierre
description Abstract We report here a new efficient regioselective synthetic route to 4-bromomethylacridine and to 4,5-bis-(bromomethyl)acridine, two interesting starting materials for various 4-methyleneacridine and 4,5-bis-(methylene)acridine derivatives, in one step by direct bromomethylation of acridine with bromomethylmethylether (BMME). We also describe some biologically interesting diesters derivatives from the corresponding 4,5-bis(hydroxymethyl)acridine precursor.
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title Reactivity of the Acridine Ring: One-Pot Regioselective Single and Double Bromomethylation of Acridine and Some Derivatives
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