Scalable Synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one: An Important Building Block of the Antidiabetic Drug Glimepiride

Abstract A four-step, practical, and easily scalable synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one, an important building block of the antidiabetic drug glimepiride, has been accomplished. Key features are the synthesis of 3-methyl-4-hydroxy-2-butenolide in water and triflic acid mediate...

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Veröffentlicht in:	Synthesis (Stuttgart) 2020-11, Vol.52 (22), p.3480-3484
Hauptverfasser:	Chavan, Subhash P., Pawar, Ambaji A., Patil, Niteen B., Kadam, Appasaheb L., Shinde, Shrikrishna S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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